Vulnerable Plaque, Characteristics, Detection, and Potential Therapies

Journal of Cardiovascular Development and Disease

Anouar Hafiane¹ 

[1] Department of Medicine, Faculty of Medicine and Research Institute of the McGill University, Health Centre, McGill University, Montreal, QC H4A 3J1, Canada;

关键词: plaque;    atherosclerosis;    regression;    thrombosis;    cardiovascular disease;   

DOI  :  10.3390/jcdd6030026

来源: DOAJ

【 摘 要 】

Plaque development and rupture are hallmarks of atherosclerotic vascular disease. Despite current therapeutic developments, there is an unmet necessity in the prevention of atherosclerotic vascular disease. It remains a challenge to determine at an early stage if atherosclerotic plaque will become unstable and vulnerable. The arrival of molecular imaging is receiving more attention, considering it allows for a better understanding of the biology of human plaque and vulnerabilities. Various plaque therapies with common goals have been tested in high-risk patients with cardiovascular disease. In this work, the process of plaque instability, along with current technologies for sensing and predicting high-risk plaques, is debated. Updates on potential novel therapeutic approaches are also summarized.

【 授权许可】

Unknown