Synthesis of size tunable gold nanoparticles polymeric hybrid based on molecular nanocages

Micro & nano letters

article

Desuo Zhang¹  Jiaqing Xiong¹  Chenmei Li¹  Yan Zhang¹  Guoyang W. Toh²  Hong Lin¹  Yuyue Chen¹ 

[1] National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University;Department of Physics, Faculty of Science, National University of Singapore

关键词: nanoparticles;    gold;    nanofabrication;    organic-inorganic hybrid materials;    particle size;    polymers;    Au;    catalysis;    particle size;    volume confinement effect;    reactive amino groups;    three-dimensional nanocage structures;    polyamide network polymer;    molecular nanocages;    size tunable gold nanoparticles polymeric hybrid;   

DOI  :  10.1049/mnl.2013.0728

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Background and Aims: Post-dural puncture headache (PDPH) is a common cause of morbidity in patients subjected to dural puncture for spinal anesthesia. PDPH is mostly a benign condition but can lead to delayed hospital discharge and considerable morbidity for the parturient. We aimed to study whether there is a positive role of prednisolone in post dural puncture headache management (after spinal anesthesia) in patients undergoing lower segment cesarean section (LSCS). Methodology: A randomized controlled trial was conducted at department of gynecology and obstetrics, in Combined Military Hospital (CMH), Nowshera, from April 2018-September 2018. A sample size of 60 patients was determined through WHO calculator. Patients were selected through non probability consecutive sampling after ethical committee approval and consent forms were taken. Patients were randomly categorized into two groups. Group A was given tablet prednisolone while Group B was given a placebo tablet. Patients were followed for pain measurement using visual analogue scale (VAS). Data were analyzed using SPSS version 24. T-test and Chi-square test were applied. A p ≤ 0.05 was considered significant.Results: A total of 60 women undergone c sections were included in study. Mean age of women was 28.5 years ± 4.3. Mean pain scores were significantly reduced in prednisolone group as compared to placebo at 24, 48, 72 and 96 h (p = 0.00). Majority of patients in placebo group had severe headache as compare to oral prednisolone group after 96 h (p = 0.00).Conclusion: Post-Dural Puncture Headache is a major complications following LSCS in spinal anesthesia. Oral prednisolone usage is very effective in lowering severity of headache and duration of PDPH. Oral prednisolone also limits adverse events associated with PDPH after LSCS performed in spinal anesthesia.

【 授权许可】

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