期刊论文详细信息
Micro & nano letters
Effect of sonication time on the characteristics of nanophase hydroxyapatite crystals synthesised by the sol–gel technique
article
Songkot Utara1  Jutharatana Klinkaewnarong2 
[1] Division of Chemistry, Faculty of Science, Udon Thani Rajabhat University;Program in Physics, Faculty of Science, Udon Thani Rajabhat University
关键词: sol-gel processing;    calcium compounds;    mixing;    drying;    calcination;    X-ray diffraction;    transmission electron microscopy;    Fourier transform spectra;    infrared spectra;    crystal structure;    particle size;    sonication time effect;    nanophase hydroxyapatite crystal characteristics;    sol-gel technique;    hydroxyapatite structure;    diammonium hydrogen phosphate;    calcium nitrate tetrahydrate;    mixing;    drying;    calcination;    crystallisation;    functional groups;    X-ray diffraction;    XRD;    transmission electron microscopy;    TEM;    Fourier transform infrared spectroscopy;    FTIR;    crystalline sizes;    crystalline fraction;    particle size;    carbonate group concentration;    frequency 25 kHz;    temperature 25 degC;    time 5 min;    time 10 min;    Ca10(PO4)6(OH)2;    size 50 nm to 58 nm;    time 40 min;    time 30 min;    time 20 min;   
DOI  :  10.1049/mnl.2014.0316
学科分类:计算机科学(综合)
来源: Wiley
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【 摘 要 】

Background & objectives: Intraperitoneal instillation of local anesthetic agents with or without opioids has been proposed to reduce postoperative pain after laparoscopic procedures. So, we did a prospective, randomized, double blind, placebo-controlled study to compare the effectiveness of intraperitoneal 0.2% ropivacaine alone or with nalbuphine for postoperative analgesia in laparoscopic cholecystectomy. Methodology: A total of 90 patients of ASA class I and II for laparoscopic cholecystectomy procedures were enrolled for this study. The drug was instilled intraperitoneally before the removal of trocar at the end of surgery. In Group-1 (n=30): 0.2% ropivacaine + 2 mg nalbuphine in 20 ml, in Group-2 (n=30): 20 ml 0.2% ropivacaine alone and in Group-3 (n=30) normal saline 20 ml were installed intraperitoneally. Postoperative pain was assessed by visual analogue score for 24 hours and when VAS >4, rescue analgesic was administered. The total amount of rescue analgesics given in the postoperative period and side effects were noted in this study. Results: Intraperitoneal instillation of ropivacaine with nalbuphine significantly reduced immediate postoperative VAS scores (1.0667 ± 0.78, 3.36 ± 1.37 and 5.53 ± 1.85 in Group-1, 2 and 3 respectively). It also reduced VAS at 8 hours after surgery in the Group-1 (0.8 ± 0. 71) compared to the Group-2 VAS (2.73 ± 1.25). The time for the first rescue analgesic requirement was significantly higher in Group-1 (6.15 h) compared to the Group-2 (4.51 h). Total amount of rescue analgesic was required more in Group-2 and Group-3 compared to Group-1. Conclusion: Addition of nalbuphine to intraperitoneal ropivacaine significantly prolonges the time to first rescue analgesic requirement and reduces the total consumption of rescue analgesics in 24 hours without any significant increase in adverse events in laparoscopic cholecystectomies.

【 授权许可】

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