Investigation of penetration using atomic force microscope: potential biomarkers of cell membrane

Micro & nano letters

article

Runhuai Yang¹  Lianqing Liu²  Changlin Zhang²  Ning Xi²  Jie Yang¹ 

[1] Department of Precision Machinery & Precision Instrumentation, University of Science and Technology of China;Shenyang Institute of Automation, Chinese Academy of Sciences;Department of Mechanical and Biomedical Engineering, City University of Hong Kong

关键词: atomic force microscopy;    organic compounds;    cellular biophysics;    biomembranes;    drugs;    atomic force microscopy;    cell membrane biomarkers;    penetration force;    drug treatment;    dimethyl sulfoxide;   

DOI  :  10.1049/mnl.2014.0693

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

There is an ever increasing number of invasive cardiovascular procedures performed annually all over the world. Most of these procedures are known to have a high complication rate; the most common cause of these complications being the surgical stress response with resultant impaired myocardial oxygen supply and demand ratio. The use of dexmedetomidine in cardiac anesthesia has shown promising results in decreasing the complication rates in these patients. It is shorter acting, highly selective alpha-2 adrenoceptor agonist and has analgesic, sedative, anxiolytic and sympatholytic properties. Published studies and meta-analyses have demonstrated beneficial role of perioperative use of dexmedetomidine in cardiac anesthesia. It is relatively a new drug and in order to further confirm its beneficial effects during cardiac anesthesia, more well designed, clinical trials are needed to make evidence based recommendations for its use in specific circumstances and establish its permanent place in cardiac anesthesia.

【 授权许可】

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