Facile synthesis of polydopamine/reduced graphene oxide nanosheets with incorporated copper ions for high antibacterial performance

Micro & nano letters

article

Aiying Guo¹  Yanfeng Sun²  Xiaoyue Xu¹  Xiumin Yu¹  Xiaojie Wu¹  Aijun Cai¹  Ling Qin³ 

[1] College of Agronomy and Biotechnology, Hebei Normal University of Science & Technology;Ocean College, Agricultural University of Hebei;College of Bioscience and Bioengineering, Hebei University of Science and Technology

关键词: nanocomposites;    nanofabrication;    cellular biophysics;    polymerisation;    biomedical materials;    antibacterial activity;    self-assembly;    microorganisms;    copper;    graphene compounds;    filled polymers;    nanomedicine;    biomembranes;    copper ions;    antibacterial performance;    bioadhesive PDA;    GO nanosheets;    facile synthesis;    polydopamine-reduced graphene oxide nanosheets;    green approach;    coating;    self-assembly;    oxidative polymerisation;    Escherichia coli;    Staphylococcus aureus;    E;    coli cell death;    cell membranes;    intracellular reactive oxygen species;    antibacterial agents;    Cu-CO;   

DOI  :  10.1049/mnl.2019.0524

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

In this work, a facile and green approach for the synthesis of polydopamine/reduced graphene oxide nanosheets with incorporated copper ions (Cu/PDA/RGO) has been reported using bioadhesive PDA. During the process, the coating of PDA occurred through self-assembly and oxidative polymerisation, involving both the reduction of GO nanosheets and immobilisation of Cu ions. The Cu/PDA/RGO nanosheets showed effective and efficient antibacterial performance against Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ). The antibacterial mechanism of the Cu/PDA/RGO nanosheets was also investigated. The death of E. coli cells could be attributed to the disruption of their cell membranes and increased levels of intracellular reactive oxygen species (ROS). However, due to the direct contact between the Cu/PDA/RGO nanosheets and cells, the production of high level ROS ultimately led to the death of S. aureus cells. This research provides a new idea for the synthesis of antibacterial agents.

【 授权许可】

CC BY|CC BY-ND|CC BY-NC|CC BY-NC-ND