Folate-intercalated layered double hydroxide as a vehicle for cyclophosphamide, a non-ionic anti-cancer drug

Micro & nano letters

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Gregorio Guadalupe Carbajal Arízaga¹  Cecilia Sánchez Jiménez¹  Karina J. Parra Saavedra¹  Adriana M. Macías Lamas²  Ana M. Puebla Pérez² 

[1] Universidad de Guadalajara;Departamento de Farmacobiología, Universidad de Guadalajara

关键词: drug delivery systems;    drugs;    cancer;    infrared spectra;    X-ray diffraction;    biomedical materials;    folate-intercalated LDH;    layered double hydroxide;    nonionic anticancer drug;    interlayer anion;    inorganic anion;    neutral molecule;    interlayer space;    long-chain surfactant;    hydrophobic molecule;    hydrogen bond;    hydrophobic interaction;    infrared spectroscopy;    X-ray diffraction;    imidazole;    urea;    cyclophosphamide-LDH product;    LDH-based vehicle;    chemotherapy;   

DOI  :  10.1049/mnl.2016.0106

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Arnold–Chiari malformation (ACM) type I with syringomyelia patients can present with autonomicdysfunction. Anesthesia management requires careful preoperative assessment, identification of potentialproblems and appropriate planning. We present a case report of a29- years female diagnosed as ACM Type I with syrinngomyelia associated with autonomic dysfunctionwas operated for foramen magnum decompression. Glidescope was used for intubation to preventneurological damage associated with neck movement. After placing in prone position patient hadhypotension with tachycardia. Supine position was immediately resumed; managed with intravenous(IV) fluid and vassopressure. Patient was again placed in prone position after normalization of bloodpressure. Her postoperative period was uneventful.

【 授权许可】

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