Electrospinning of aligned medical grade polyurethane nanofibres and evaluation of cell–scaffold interaction using SHED stem cells

Micro & nano letters

article

Javad Yekrang¹  Dariush Semnani¹  Mohammad H. Beigi²  Saeed Karbasi³ 

[1] Department of Textile Engineering, Isfahan University of Technology;Department of Cellular Biotechnology, Cell Science Research Center, Royan Institute for Biotechnology;Department of Biomaterials and Tissue Engineering, School of Advance Technology in Medicine, Isfahan University of Medical Sciences

关键词: cellular biophysics;    tissue engineering;    electrospinning;    nanofibres;    polymer fibres;    nanomedicine;    biomedical materials;    nanofabrication;    scanning electron microscopy;    field emission electron microscopy;    statistical analysis;    dentistry;    electrospinning;    aligned medical grade polyurethane nanofibres;    cell-scaffold interaction;    SHED stem cells;    tissue engineering;    elastic tissues;    tendon;    ligament;    vascular grafts;    arterial grafts;    PU nanofibres;    morphology;    extracellular matrix;    Elasthane 55D nanofibres;    rotating drum;    flow rates;    collector speeds;    nanofibre alignment;    nanofibre diameter;    field emission scanning electron microscopy;    FESEM;    nanofibrous webs;    human exfoliated deciduous tooth;    statistical results;    fibre alignment index;    cell growth;    esophagus prosthesis;   

DOI  :  10.1049/mnl.2017.0035

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Introduction: Gabapentin possesses antihyperalgesic and antiallodynia properties and has a definite role in neuropathicpain relief. In this study, we tried to determine whether preemptive use of gabapentin can result in reduction of intra andpostoperative pain and narcotic (nalbuphine) requirements in patients undergoing total abdominal hysterectomy (TAH).Methods: In this randomized, double-blind controlled trial, 35 patients (study group) undergoing TAH receivedgabapentin 1200 mg and 35 patients (control group) received placebo orally two hours before induction of anesthesia.Intra-operatively, an increase in blood pressure and heart rate were taken as an indicator of pain during surgery andnalbuphine at 0.05-mg/kg body weight was administered as a rescue analgesia. Postoperatively, for the initial 24 hours,pain was assessed on a Visual Analogue Scale (VAS score 1-10, score 1-3 considered mild pain, 4-7 moderate pain &8-10 as severe pain). If score was more than 3 a top up dose of nalbuphine 0.05 mg/kg was administered intravenously.Total nalbuphine consumption during the intraoperative period and initial 24 hours postoperative period was recordedfor each patient.Results: Thirty four patients in the gabapentin group (study group) and 35 patients in the Placebo group (control group)completed the study. Overall, pain scores in the gabapentin group were significantly lower as compared to the Placebogroup. The total nalbuphine consumption was 13.2 ± 4.7 mg (mean ± SD) in the gabapentin group versus 24.3 ± 9.2mg in the Placebo group (P < 0.001).

【 授权许可】

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