How direct electrospinning in methanol bath affects the physico-chemical and biological properties of silk fibroin nanofibrous scaffolds

Micro & nano letters

article

Zhina Hadisi¹  Jhamak Nourmohammadi¹  Nooshin Haghighipour²  Shafagh Heidari² 

[1] Biomaterials Group, Faculty of New Sciences and Technologies, University of Tehran;National Cell Bank, Pasteur Institute

关键词: electrospinning;    proteins;    nanofibres;    cellular biophysics;    biomedical materials;    bone;    direct electrospinning;    methanol bath;    physicochemical;    biological properties;    silk fibroin nanofibrous scaffolds;    crystalline silk fibroin nanofibres;    soaking time;    wet electrospun mats;    average fibre diameter;    crystallinity;    cellular viability;    osteoblast like cells;    MG63 cells;    fibroin mats;    bone regeneration;   

DOI  :  10.1049/mnl.2016.0301

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Neurological deficits are the rare but unacceptable complications of neuraxial blockade. We report threecases of vaginal hysterectomy performed under combined spinal epidural anesthesia (CSE) using 3 mlof 0.5% hyperbaric bupivacaine (15 mg) in subarachnoid space followed by epidural analgesia top upafter wearing off of spinal anesthesia. One patient complained of unilateral paresthesia and numbnesson left thigh with no motor involvement in the evening postoperatively, two patients developed bilateralparesthesia and numbness over anterior thigh and knees and motor weakness in both lower limbs on nextday morning. Epidural catheter was removed immediately and treated with oral tab prednisolone and tabmethylcobalamin. All patients had complete recovery and were discharged after a week. Unrecognisedmechanical irritation of the nerve roots by epidural catheter is thought to be the cause. We conclude thatpatients with epidural catheter should be monitored and on appearance of any neurological symptomsthe catheter be removed to prevent permanent neurological sequelae.

【 授权许可】

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