Assessing the physical and mechanical properties of poly 3-hydroxybutyrate-chitosan-multi-walled carbon nanotube/silk nano–micro composite scaffold for long-term healing tissue engineering applications

Micro & nano letters

article

Mohammad H. Mirmusavi¹  Saeed Karbasi¹  Dariush Semnani²  Mohammad Rafienia¹  Anousheh Zargar Kharazi¹ 

[1] Department of Biomaterials and Tissue Engineering, School of Advance Technology in Medicine, Isfahan University of Medical Sciences;Department of Textile Engineering, Isfahan University of Technology

关键词: multi-wall carbon nanotubes;    tissue engineering;    biomedical materials;    filled polymers;    nanocomposites;    nanomedicine;    electrospinning;    nanofabrication;    microfabrication;    scanning electron microscopy;    Fourier transform infrared spectra;    contact angle;    tensile strength;    tensile testing;    porosity;    hydrophilicity;    nanofibres;    physical properties;    mechanical properties;    poly 3-hydroxybutyrate-chitosan-multiwalled carbon nanotube-silk nanocomposite scaffold;    poly 3-hydroxybutyrate-chitosan-multiwalled carbon nanotube-silk microcomposite scaffold;    long-term healing tissue engineering applications;    nanohybrid scaffolds;    electrospinning;    microhybrid scaffolds;    poly 3-hydroxibutyrate-chitosan-multiwalled carbon nanotube nanofibres;    silky knitted microfibers;    MWNT concentration;    morphological properties;    scanning electron microscopy;    Fourier transform infrared spectroscopy;    FTIR spectroscopy;    water contact angle test;    tensile strength test;    fibre diameter distribution;    porosity percentage;    crystallinity structures;    silk fibroin;    hydrophilicity;    biomimetics;    extracellular matrix;    C;   

DOI  :  10.1049/mnl.2017.0725

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Multiple sclerosis (MS) is the most common chronic autoimmune neuromuscular disease with prevalence rates that has increased in Iran especially in Isfahan population. In MS, there is a coordinated attack of innate and adaptive immune cell against central nervous system (CNS). Concurrence of autoimmune disorders is prevalent such as the concurrence of MS and myasthenia gravis (MG). MS could be associated with MG although they have different target organs. The aim of this study was to assess the effects of thymectomy as a proper treatment for both MS and MG. We studied patients who were referred to our MS clinic with the diagnosis of definite MS and MG made by a neurologist according to Isfahan MS Clinics, Isfahan, Iran (2010-2013). Age, sex, family and medical history, general neurologic symptoms and physical examination in all patients were recorded. We analyzed the clinical, laboratory, and brain magnetic resonance imaging (MRI) findings of the patients with MS and MG in an attempt to identify parameters involved in these diseases. We surveyed 12 patients (0.3%) out of 3920 patients who had both MS and MG. One of these patients had secondary progressive MS and the others had relapsing-remitting MS (RRMS). Five of them experienced thymectomy operation and about 4 (80%) of them completely improved after thymectomy, none of the symptoms of diseases were seen. Almost all of patients completely improved after thymus removal. We suggest thymectomy could be a valuable therapy for MS/ MG patients. However, more investigations should be done on this issue.

【 授权许可】

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