期刊论文详细信息
Micro & nano letters
Deep insight into linearity and NQS parameters of tunnel FET with emphasis on lateral straggle
article
Sayani Ghosh1  Kalyan Koley2  Chandan K. Sarkar1 
[1] Nano Device Simulation Laboratory, Electronics and Telecommunication Engineering Department, Jadavpur University;Department of Electronics Engineering, Indian Institute of Technology Dhanbad
关键词: tunnel transistors;    field effect transistors;    ion implantation;    silicon;    elemental semiconductors;    semiconductor device reliability;    NQS parameter;    tunnel FET;    tunnel field-effect transistor;    DG-metal-oxide-semiconductor FET;    reduced off-state current;    lower subthreshold swing;    small-signal-radiofrequency methodology;    RF methodology;    lateral straggle variation;    tilt angle variation;    ion implantation process;    RF intrinsic parameter performance;    double gate TFET;    nonquasistatic RF bias-dependent parameter;    gate-to-drain intrinsic resistance;    intrinsic capacitance;    intrinsic time delay;    reliability;    higher-order transconductance;    size 1 nm to 5 nm;    Si;   
DOI  :  10.1049/mnl.2017.0326
学科分类:计算机科学(综合)
来源: Wiley
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【 摘 要 】

Background:  Tumour lysis syndrome is a common complication of haematological malignancies and has historically been managed with hyperhydration, urine alkalinisation and allopurinol with renal dialysis reserved for patients in acute renal failure. Rasburicase has been shown to drastically reduce the need for dialysis; however, its use is limited in developing countries owing to its cost and availability. Aim:  This retrospective analysis aimed to compare the cost to state per patient of rasburicase compared to dialysis in the management and prevention of tumour lysis syndrome in paediatric patients presenting with haematological malignancies admitted to Red Cross War Memorial Children’s Hospital (RCWMCH). Setting:  Red Cross War Memorial Children’s Hospital. Methods:  Patients from two consecutive 35 month periods, before and after the availability of rasburicase at RCWMCH, were grouped according to treatment modality, and the cumulative costs of hospitalisation, dialysis and drug administration were compared. Results:  The groups were comparable in mean age and gender. The mean total length of hospital stay was 10.04 days shorter for the rasburicase group than the dialysis group with the average cost per patient in the rasburicase group being R40 989.64 lower than the dialysis group. Conclusion:  The use of rasburicase results in a significant per patient cost saving when compared to dialysis, which often requires intensive care admission, and results in extended hospitalisation. The study supports the continued use of rasburicase as an essential adjunct in the management and prevention of tumour lysis syndrome, reaffirming its use as a cost-effective and efficient drug.

【 授权许可】

CC BY|CC BY-ND|CC BY-NC|CC BY-NC-ND   

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