One-step synthesis of amino-functionalised magnetic mesoporous silica and synergistic adsorption kinetics of tetracycline and copper

Micro & nano letters

article

Mancheng Zhang¹  Wei Wang¹  Zengyin Zhu¹  Changsheng Qu¹  Qing Zhou²  Shui Wang¹  Liang Ding¹ 

[1] Jiangsu Province Key Laboratory of Environmental Engineering, Jiangsu Provincial Academy of Environmental Science;State Key Laboratory of Pollution Control and Resources Reuse, School of the Environment, Nanjing University

关键词: pH;    desorption;    polymerisation;    transmission electron microscopy;    mesoporous materials;    nanomagnetics;    adsorption;    scanning electron microscopy;    nanofabrication;    X-ray diffraction;    silicon compounds;    particle size;    surface morphology;    Fourier transform infrared spectra;    water treatment;    copper;    organic compounds;    nanoparticles;    magnetic particles;    SiO2;    Cu;    aquatic environment;    antibiotics;    amine groups;    pH-responsive speciation;    tetracycline;    adsorption kinetics;    long-range ordered pore structure;    micronsized particle size;    transmission electron microscopy;    Fourier transform infrared spectroscopy;    scanning electron microscopy;    nitrogen adsorption–desorption;    microscopic morphology;    one-step copolymerisation method;    amino-functionalised magnetic mesoporous silica;   

DOI  :  10.1049/mnl.2017.0838

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Isradipine related to dihydropyridine (DHP) class of calcium channel blockers (CCBs). It is  used to treat hypertension, angina pectoris, as well as Parkinson disease. It goes under the BCS class II drug (low solubility-high permeability). The drug will experience extensive first-pass metabolism in liver, thus, oral bio-availability will be approximately15 to 24 %.         The aim of the study is preparing stable oral oil in water (o/w) nanoemulsion of isradipine to promote the colloidial dispersion of isradipine in the nano range, so that it may be absorded by intestinal lymphatic transport in order to avoid hepatic first-pass metabolism (israpidine undergoes 15-24% first pass metabolism) and increase drug bioavailability.        The solubility study was carried out in various vehicles for selecting best solvent  for dissolving isradipine. Pseudo-ternary phase diagrams is formed at (1:1, 1:2, 1:3, 1:4 and 2:1) ratios related to Smix (co-surfactant and surfactant).  There are 11 nano-emulsion was  prepared through the use of many concentrations of ( Transcutol, Tween20, and Triacetin). All formulations assessed for (in-vitro drug dissolution, pH measurement, viscosity, drug content, polydispersity index, particle size distribution, thermodynamic stability, dye test, and light transmittance). It is indicated that the extent as well as the rate of release regarding all the prepared formulations have considerably higher in comparison to that of crude drug powder. Results of characterization were explained that isradipine  nano emulsion (NE9) with S mix(1:4) : oil : deionized water (40: 5: 55) ratio was the optimized formula that has droplet size range (177.1nm), the lowest value of polydispersity index (0.12), the highest percent of drug content (99.7%) typical pH value for oral administration (5.21) , good percent of light transmittance (99.86 %), the range of viscosity (65.12 -25.2 m Pas. sec.) was suitable for oral administration, also the isradipine’s in vitro release has been considerably higher. It can be concluded that nano emulsion drug delivery system (DDS) can be considered as an encouraging method for improving the stability, dissolution and solubility of formulation.

【 授权许可】

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