Agglomeration of the poly(butadiene-styrene) latex triggered by CO 2 bubbling and the preparation of poly(methyl methacrylate-butadiene-styrene) core/shell particles with a wide size distribution

Micro & nano letters

article

Jianwu Sun¹  Yiming Jiang²  Xiaoteng Zhou¹  Bo Ning¹  He Qin¹  Chengyou Kan¹ 

[1] Department of Chemical Engineering, Key Laboratory of Advanced Materials of Ministry of Education, Tsinghua University;Lescent (China) Advanced Materials Co. Ltd

关键词: polymerisation;    rubber;    transmission electron microscopy;    scanning electron microscopy;    particle size;    emulsions;    pH;    polymer structure;    wide particle size distribution;    seeded emulsion copolymerisation;    pH value;    CO2 bubbling;    poly(methyl methacrylate-butadiene-styrene) core-shell particles;    agglomerated butadiene-styrene rubber latexes;    SBR particle size;    MBS particles;    NaOH aqueous solution;    transmission electron microscopy;    rubber volume fraction;    shell thickness;    scanning electron microscopy;    size 100.0 nm;   

DOI  :  10.1049/mnl.2018.5305

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Darifenacin hydrobromide is a selective ?3 receptor antimuscarinic drug and it is used in the management of urinary frequency, urgency, and incontinence in detrusor instability. It slightly soluble in water, undergoes extensive hepatic first-pass metabolism and has short elimination half-life (3–4 hours). Therefore, It has low bioavailability (15.4 % - 18.6 %). Darifenacin hydrobromide loaded NLCs were formulated by emulsification sonication using different ratios of solid lipid to liquid lipid, different types of surfactants, and different concentration of surfactants. Formula sixteen was considered as an optimized formula based on its particle size, PDI, zeta potential and entrapment efficiency. Formula sixteen subjected to further characterization such as DSC, FT – IR, XRD, AFM, and release study. FT-IR and DSC studies showed no interaction between drug and excipients. XRD study showed that drug in amorphous form. AFM study showed discrete lipid nanoparticles with no aggregation. Release study showed burst release in the first hour followed by sustained and controlled release up to 12 hours. The over all study showed the potential of NLC as a carrier for enhancing the bioavailability of darifenacin hydrobromide as compared to the conventional dosage form.

【 授权许可】

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