Synthesis and characterisation of polymer containing dye-affinity ligand grafted to magnetic nanoparticles for enteric insulin delivery

Micro & nano letters

article

Babak Izadi Vahedi¹  Amir Heydarinasab¹  Homayon Ahmad Panahi²  Mohsen Jahanshahi³ 

[1] Department of Chemical Engineering, Science and Research Branch, Islamic Azad University;Department of Chemistry, Central Tehran Branch, Islamic Azad University;Nanobiotechnology Research Laboratory, School of Chemical Engineering, Babol University

关键词: scanning electron microscopy;    nanofabrication;    polymers;    dyes;    magnetic particles;    polymerisation;    drugs;    thermal analysis;    transmission electron microscopy;    drug delivery systems;    pH;    nanomagnetics;    organic compounds;    sorption;    biomedical materials;    nanoparticles;    adsorption;    iron compounds;    Fourier transform infrared spectra;    thermogravimetric analysis;    elemental analysis;    transmission electron microscopy;    magnetic nanocarrier;    enteric insulin delivery;    insulin uptake;    scatchard analysis;    dye-affinity ligand nanocarrier;    Procion blue nanocarrier;    magnetic nanoparticles;    surface grafting;    Procion blue MX-R;    modified iron oxide nanoparticles;    3-mercaptopropyltrimethoxysilane;    grafted nanocarrier;    free radical polymerisation;    Langmuir model;    Temkin model;    Freundlich model;    Redlich–Peterson models;    pH 5;    Fourier transform infrared spectroscopy;   

DOI  :  10.1049/mnl.2017.0384

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Chronic Kidney Disease (CKD) is a public health problem and many studies support the link between kidney dysfunction and cardiovascular events.  Aldosterone has been shown for decades that a plasma aldosterone concentration is elevated in CKD. Whilst, Osteoprotegerin (OPG), after its capacity to protect bone, also osteoprotegerin is elevated in patients with chronic kidney disease (CKD), where it could predict the deterioration of kidney function, cardiovascular, vascular events and all-cause mortality. On the other hand, fibroblast growth factors (FGFs), in patients with CKD, its levels seem to increase progressively as kidney function worsens. The aim of the present study is to assess the correlations between serum osteoprotegerin, aldosterone and fibroblast growth factor-23 levels in patients with chronic kidney disease stage (II-IV) with and without cardiovascular events. The study includes fifty-nine patients with chronic kidney disease(CKD) and according to CKD-EPI /Creatinine/ 2009 equation to be allocated as stage II-IV, patients were divided into three groups: Group1 (29 patients) with chronic kidney disease(CKD) stage (II-IV) with cardiovascular events. Group2 (30 patients) with chronic kidney disease stage (II-IV) without cardiovascular event, to be compared with Group 3(23 apparently healthy subjects), age and sex matched to that of patients. Serum obtained from their blood specimens to measure; glucose, urea, creatinine, calcium, phosphate, sodium, potassium, aldosterone, FGF-23, Osteoprotergen. Data analysis showed that fasting serum glucose levels of CKD patients (with and without CV disorder) had significantly higher values as compared to the controls (76.5% and 29% respectively). Serum Aldosterone, FGF-23, OPG levels were presented with no significant variation among studied groups with CV events or those without CV events.

【 授权许可】

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