Indium tin oxide coated PET for differential pH-sensing using field-effect transistor based sensor

Micro & nano letters

article

Naser Mokhtarifar¹  Frank Goldschmidtboeing¹  Peter Woias¹ 

[1] Department of Microsystems Engineering (IMTEK), University of Freiburg

关键词: polymer films;    MOSFET;    tin compounds;    chemical sensors;    indium compounds;    pH measurement;    micromachining;    amplifiers;    sheet materials;    laser beam machining;    indium tin oxide coated PET;    differential pH-sensing;    polyethylene terephthalate substrate;    pH-sensitivity;    gate-terminal;    metal–oxide–semiconductor field-effect transistor;    extended gate field-effect transistor pH-sensor;    sensor signal;    constant-charge amplifier circuitry;    reference electrode;    measurement cell;    pH-measurement;    pseudoreference electrode;    low-cost EGFET-based pH-sensor;    field-effect transistor based sensor;    commercial ITO-PET sheet;    electrode shape;    EGFET pH-sensor;    moulded ITO-PET electrode;    laser micromachining quality;    noise level;    high drift signal rate;    buffer solution;    InSnO;   

DOI  :  10.1049/mnl.2018.5240

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

The spectrum of clinical efficacy of Methotrexate (MTX) is broad in that MTX is used in the treatment of certain cancers, severe psoriasis and rheumatoid arthritis.Various mechanisms by which cancer cells grown in tissue culture become resistant to anticancer drugs. The use of multiple  drugs with different mechanisms of entry into cells and different cellular targets allows for effective chemotherapy and high cure rates. In an efforts to develop effective strategies that increase the therapeutic potential of anticancer drugs with less systemic toxicity ,are being directed  towards the investigation of dietary supplements and other phytotherapeutic agents for their synergistic efficacy in combination with anticancer drugs. A promising approach to improve the cancer cell selectivity of methotrexate is the chemical transformation into reversible derivatives which convert the conjugate to the parent drug by virtue of enzyme within cancer tissue. The present study includes the synthesis of  two derivatives of methotrexate which are :-Schiff base methotrexate-silibinin conjugate ( compound 5), and Methotrexate-silibinin conjugate (compound 6).The synthesis  of the target compounds was  accomplished following multistep reaction procedures. The chemical reactions were followed up and purity of the products was checked by TLC. The structures of the final compounds and their intermediates were characterized and identified by their melting points, infrared spectroscopy, 1H-NMR and elemental microanalysis(C H N S).The anticancer activity of these compounds was investigated by HEP-2 cell line(Larynx carcinoma), which showed  that compounds 5 and 6 have the higher activity than methotrexate or silibinin alone.These are promising data for the discovery of new anticancer agents in future. These compounds may deliver the parent drug  selectively  into the cancer cells to be hydrolyzed by enzymes that are elevated in  tumor tissues compared with normal tissues .

【 授权许可】

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