Microelectromechanical system-based biocompatible artificial skin phantoms

Micro & nano letters

article

Chien-Hao Liu¹  Yin-Chen Huang²  Shang-Hsuan Li¹  Yen-An Chen¹  Wesley Z Wang³  Jia-Shing Yu⁴  Wen-Pin Shih¹ 

[1] Department of Mechanical Engineering, National Taiwan University;Institute of Applied Mechanics, National Taiwan University;Taipei American School;Department of Chemical Engineering, National Taiwan University

关键词: photoresists;    microfabrication;    phantoms;    gelatin;    skin;    laser ablation;    cellular biophysics;    biomedical materials;    size 620.0 cm;    size 57.0 mum;    size 20.0 mum;    wearable bioelectronic devices;    attachable bioelectronic devices;    microholes;    resistivity;    impedance;    electrical properties;    phantom model;    laser ablation techniques;    artificial phantom;    physical properties;    scalable phantom;    human skin;    physical interactions;    microelectromechanical system-based biocompatible artificial skin phantoms;   

DOI  :  10.1049/mnl.2018.5112

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Chronic inflammation can induce proliferative events and posttranslational DNA modifications in prostate tissue through oxidative stress. The present study was designed to evaluate the changes in serum levels of TNF-α, malomdialdehyde (MDA) and total antioxidant status (TAS) patients with different stages of malignant prostatic cancer (PCa) and benign prostatic hyperplasia (BPH). One hundred males (age range of 58-72 years) with different stages of malignant PCa were recruited from the Radiotherapy and Nuclear Medicine Teaching Hospital in Baghdad during the period from September 2010 to April 2011. The patients were categorized according to the 4 disease stages (I, II, III, and IV); 25 patients with benign prostatic hyperplasia (BPH) and 25 normal healthy subjects were considered as comparator groups. Blood samples were taken from all subjects for analysis of TNF-α TAS and MDA levels. The results showed significant differences between the four stages of PCa patients in all parameters; however, highly significant difference was observed in stage IV compared to control and BPH patients. In conclusion, TNF-α and total antioxidant status could be utilized for marking the advanced stages of malignant PCa.

【 授权许可】

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