High-sensitivity microelectromechanical systems-based tri-axis force sensor for monitoring cellular traction force

Micro & nano letters

article

Nguyen Thanh-Vinh¹  Tomoki Omiya²  Takuya Tsukagoshi¹  Kayoko Hirayama²  Kentaro Noda²  Kiyoshi Matsumoto³  Isao Shimoyama¹ 

[1] Information and Robot Technology Research Initiative, The University of Tokyo;Department of Mechano-Informatics, Graduate School of Information Science and Technology, The University of Tokyo;Faculty of Science and Engineering, Toyo University

关键词: force sensors;    force measurement;    traction;    microsensors;    silicon;    elemental semiconductors;    photoresists;    photoresistors;    piezoresistive devices;    compensation;    photodetectors;    microfabrication;    microelectromechanical system;    triaxis force sensor;    cellular traction force monitoring;    single cell traction force measurement;    micropillar;    cross-shaped Si structure;    double-layer photoresist cap;    piezoresistor;    shear force measurement;    normal force measurement;    trypsin treatment;    osteosarcoma cell;    microfabrication;    Si;   

DOI  :  10.1049/mnl.2016.0246

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Objective: Carboprost is used to prevent postpartum hemorrhage in pregnant patients but is associatedwith severe nausea and vomiting .This a study was done to compare ondansetron and P6 point acupuncturestimulation for prevention of carboprost induced nausea and vomiting.Methodology: Fifty ASA class I and II full term pregnant patients scheduled for elective cesarean sectionwere randomly allocated into Group-O (n=25) and Group-P (n=25). Subarachnoid block (SAB) wasadministered in both groups using inj.0.5% hyperbaric bupivacaine in L3-L4 interspace to achieve alevel between T4 to T6. Inj.carboprost 250 mcg was given intramuscularly after the delivery of anteriorshoulder in both groups. In addition Group-O inj. Ondansetron was given and in Group-P acupuncturewas applied at P6 acupoint. Mean arterial pressures were maintained within 20% of baseline. Both groupswere observed for nausea and vomiting for two hours postoperatively.Results: Overall incidence of nausea and vomiting was significantly less in Group-P than in Group-O,however, there was no significant difference in incidence of nausea and vomiting among the two groupswhen considered individually.Conclusion: We conclude that stimulation of P6 point by acupuncture in comparison to ondansetrondecreases the overall incidence of carboprost induced nausea and vomiting in the immediate postoperativeperiod.

【 授权许可】

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