Toxicity, morphological and structural properties of chitosan-coated Bi 2 O 3 –Bi(OH) 3 nanoparticles prepared via DC arc discharge in liquid: a potential nanoparticle-based CT contrast agent

Micro & nano letters

article

Mohsen Mohammadi¹  Atiyeh Tavajjohi¹  Azin Ziashahabi¹  Negin Pournoori²  Samad Muhammadnejad³  Hamid Delavari¹  Reza Poursalehi¹ 

[1] Department of Materials Engineering, Tarbiat Modares University;Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences;Biomolecular Imaging and Analysis Group, Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences

关键词: computerised tomography;    toxicology;    nanofabrication;    nanoparticles;    biomedical materials;    nanomedicine;    X-ray diffraction;    Fourier transform infrared spectra;    field emission scanning electron microscopy;    bismuth compounds;    polymers;    structural properties;    DC arc discharge;    computed tomography contrast agents;    X-ray attenuation;    cytotoxicity properties;    electric arc discharge;    water medium;    chitosan molecule;    X-ray diffraction analysis;    monoclinic structure;    field emission-scanning electron microscopy images;    X-ray CT;    Iohexol;    CT number;    commercial iodine contrast agent substitution;    morphological properties;    nanoparticle-based CT contrast agent;    chitosan-coated nanoparticles;    optical properties;    bismuth electrodes;    glutaraldehyde;    Fourier transform infrared analysis;    chitosan band formation;    MTT assay;    time 72.0 hour;    Bi2O3-Bi(OH)3;   

DOI  :  10.1049/mnl.2018.5145

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Recently on the dermatological fields, the serum levels and the roles of Zn, Cu and Mg have been studied especially in acne vulgaris, but the results were controversial. The aim of the present study is to investigate  a relationship between the severity of acne and the serum levels of zinc (Zn), copper (Cu) and magnesium (Mg) and to demonstrate the status of serum levels of zinc, copper, and magnesium in Iraqi male patients with acne vulgaris and to compare it with those of healthy controls.This case controlled study was conducted in the Department of Dermatology and Venerology and in the Poisoning Consultation Center of Baghdad Teaching Hospital between May 2009 to January 2010. Forty- five male patients with acne vulgaris, their ages ranged from 18-30 (21.82±3.77) years and 45 healthy male subjects as controls, their ages ranged from 18-30 (22.18±3.85) years were included in this study. Patients were subdivided into three groups according to the severity of their acne; mild acne group (n=15), moderate (n=15) and severe acne group (n=15). Investigations included serum estimation of Zn, Cu and Mg in both patient and control groups.The data obtained from this study showed that the (mean±SD) values of serum levels of Zn was significantly decreased in severe acne group compared with controls, mild and moderate type of acne group (P< 0.05). Serum Mg concentration was significantly lower in severe acne group compared with mild and moderate acne group (P< 0.05). With regard to serum Cu, there were no significant differences  among groups of patients with acne vulgaris.This study revealed a significant association between serum levels of either Zn or Mg with the severity of acne.

【 授权许可】

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