Meteorological drought analysis using copula theory and drought indicators under climate change scenarios (RCP)

Meteorological applications

article

Tayyebeh Mesbahzadeh¹  Maryam Mirakbari¹  Mohsen Mohseni Saravi¹  Farshad Soleimani Sardoo¹  Mario M. Miglietta³ 

[1] Department of Reclamation of Mountain and Arid Regions, Faculty of Natural Resources, University of Tehran;Department of Natural Engineering, Faculty of Natural Resources, University of Jiroft;Department of Earth System Science and Environmental Technologies, Institute of Atmospheric Sciences and Climate - National Research Council (ISAC-CNR)

关键词: CanESM2;    Copula;    joint and conditional return period;    SPEI;    SPI;   

DOI  :  10.1002/met.1856

学科分类：社会科学、人文和艺术（综合）

来源: Wiley

【 摘 要 】

The objective of this study was to assess the relative efficacy and tolerability of topical MJ1 compared to routine care in the treatment of histologically proven CL. A total of 150 patients with 297 lesions were randomly allocated to receive either topical MJ1 agent as a paste to applied to the lesions without cover three times a day for 20 days or routine care (intramuscular injection of meglumine antimonate 20 mg/kg/day for 2 weeks or intralesional 0.5-1 cc for a total of four injection with one week interval). The primary end point of this study was the clinical cure of the lesion. Response to treatment was assessed at 1, 2, 3 and 8 weeks after start of therapy. Of the 132 lesions treated with MJ1, the mean size of lesions decreased from 423.9 to 30.4 mm2, 111 (84.1%) were reduced in size and 21 (15.9%) not responded. Correspondingly, in the 165 lesions treated with routine care, the mean size of lesions slightly increased from 295.8 to 330.5 mm2, 82 (49.7%) were reduced in size and 83 (50.3%) not responded. The differences were statistically significant (P<0.001). No sever adverse effect occurred. The findings highlight that topical treatment with MJ1 agent was much more effective than routine care and is safe and well tolerated.

【 授权许可】

CC BY|CC BY-NC|CC BY-NC-ND