期刊论文详细信息
Reproductive medicine and biology
Evaluation of antioxidant status and oxidative stress markers in follicular fluid for human in vitro fertilization outcome
article
Takuji Nishihara1  Kazuya Matsumoto2  Yoshihiko Hosoi2  Yoshiharu Morimoto1 
[1] HORAC Grand Front Osaka Clinic;Graduate School of Biology-Oriented Science and Technology, Kindai University
关键词: eight‐hydroxydeoxyguanosine;    follicular fluid;    glutathione;    in vitro fertilization;    oxidative stress;   
DOI  :  10.1002/rmb2.12229
学科分类:工业工程学
来源: Wiley
PDF
【 摘 要 】

Purpose: Antioxidant status and oxidative stress markers in human follicular fluid (FF) surrounding oocytes may be related to the outcomes of in vitro fertilization and em‐ bryo transfer (IVF‐ET). Therefore, we herein examined the relationship between an‐ tioxidant status and oxidative stress markers in FF and the outcomes of IVF‐ET. Methods: One hundred and seventeen infertile women were included in this study. FF was obtained from mature follicles at the time of oocyte retrieval. The total anti‐ oxidant capacity (TAC) and total glutathione (GSH), vitamin C, and 8‐ hydroxy‐2′‐de‐ oxyguanosine (8‐OHdG) concentrations were measured. Results: Total GSH levels were lower in patients who had a low fertilization rate after intracytoplasmic sperm injection (ICSI). In addition, 8‐OHdG levels were higher in patients who had a low fertilization rate after ICSI and low rate of good quality blas‐ tocysts. Total GSH activity was lower in patients with endometriosis. No significant differences were noted in pregnancy outcomes. Conclusions: Total GSH and 8‐OHdG in human FF may be potential markers for fer‐ tilization in ART. Also, our findings may suggest that oxidative stress in women with infertility is associated with endometriosis.

【 授权许可】

CC BY|CC BY-NC|CC BY-NC-ND   

【 预 览 】
附件列表
Files Size Format View
RO202107100000364ZK.pdf 277KB PDF download
  文献评价指标  
  下载次数:8次 浏览次数:0次