Evaluation of fecal microbiota transplantation in Parkinson's disease patients with constipation

Microbial Cell Factories

Li-juan Xu¹  Yu-qing Zhou¹  Xiao-yi Kuai¹  Chun-li Zhou¹  Li-ping Zhang¹  Xiao-han Yao²  Yi Liu²  Shao-fang Pei² 

[1] Department of Gastroenterology, The Affiliated Suzhou Hospital of Nanjing Medical University, No. 242, Guangji Road, 215008, Suzhou, Jiangsu, China;Department of Neurology, The Affiliated Suzhou Hospital of Nanjing Medical University, No. 242, Guangji Road, 215008, Suzhou, Jiangsu, China;

关键词: Parkinson’s disease;    FMT;    Gut microbiota;    16s rDNA sequencing;    Constipation;   

DOI  :  10.1186/s12934-021-01589-0

来源: Springer

【 摘 要 】

Parkinson’s disease (PD) is a neurodegenerative disorder and 70–80% of PD patients suffer from gastrointestinal dysfunction such as constipation. We aimed to assess the efficacy and safety of fecal microbiota transplantation (FMT) for treating PD related togastrointestinal dysfunction. We conducted a prospective, single- study. Eleven patients with PD received FMT. Fecal samples were collected before and after FMT and subjected to 16S ribosomal DNA (rDNA) gene sequencing. Hoehn-Yahr (H-Y) grade, Unified Parkinson's Disease Rating Scale (UPDRS) score, and the Non-Motion Symptom Questionnaire (NMSS) were used to assess improvements in motor and non-motor symptoms. PAC-QOL score and Wexner constipation score were used to assess the patient's constipation symptoms. All patients were tested by the small intestine breath hydrogen test, performed before and after FMT. Community richness (chao) and microbial structure in before-FMT PD patients were significantly different from the after-FMT. We observed an increased abundance of Blautia and Prevotella in PD patients after FMT, while the abundance of Bacteroidetes decreased dramatically. After FMT, the H-Y grade, UPDRS, and NMSS of PD patients decreased significantly. Through the lactulose H2 breath test, the intestinal bacterial overgrowth (SIBO) in PD patients returned to normal. The PAC-QOL score and Wexner constipation score in after-FMT patients decreased significantly. Our study profiles specific characteristics and microbial dysbiosis in the gut of PD patients. FMT might be a therapeutic potential for reconstructing the gut microbiota of PD patients and improving their motor and non-motor symptoms.

【 授权许可】

CC BY