Lifestyle is associated with thyroid function in subclinical hypothyroidism: a cross-sectional study

BMC Endocrine Disorders

Linxi Wang¹  Junjun Xu¹  Beibei Li¹  Li Ma¹  Libin Liu¹  Xuelin Gao¹  Xiaoying Liu¹  Xiaohong Liu¹  Lijuan Wu¹  Chengwen Xie¹  Jingze Huang¹  Xiaoying Lin¹  Kejun Wu¹  Yanping Wang¹  Sujie Ke¹  Li Wu¹  Yu Zhou² 

[1] Department of Endocrinology and Metabolism, Fujian Medical University Union Hospital, 29 Xinquan Road, 350001, Fuzhou, Fujian, China;Department of Endocrinology and Metabolism, Fujian Medical University Union Hospital, 29 Xinquan Road, 350001, Fuzhou, Fujian, China;Department of Clinical Pharmacy and Pharmacy Administration, School of Pharmacy, Fujian Medical University, 350122, Fuzhou, Fujian, China;

关键词: Subclinical hypothyroidism;    Lifestyle;    Thyroid function;    Cross-sectional study;   

DOI  :  10.1186/s12902-021-00772-z

来源: Springer

【 摘 要 】

BackgroundFew studies have focused on the association between lifestyle and subclinical hypothyroidism (SCH). The purpose of this study was to investigate the association between lifestyle and thyroid function in SCH.MethodsThis study was a part of a community-based and cross-sectional study, the Epidemiological Survey of Thyroid Diseases in Fujian Province, China. A total of 159 participants with SCH (81 males and 78 females) and 159 euthyroid (87 males and 72 females) participants without any missing data were included in the analysis. General information and lifestyle information including sleep, exercise, diet and smoking habits of the participants was collected by questionnaire and Pittsburgh sleep quality index scale (PSQI) was collected. Thyroid stimulating hormone (TSH), free thyroxine (FT4), thyroid peroxidase antibody (TPOAb), thyroid globulin antibody (TgAb) and urine iodine concentration (UIC) were tested. Thyroid homeostasis parameter thyroid’ s secretory capacity (SPINA-GT), Jostel’s TSH index (TSHI), thyrotroph T4 sensitivity index (TTSI) were calculated. Logistic regression and multiple linear regression were performed to assess associations.ResultsCompared with euthyroid subjects, patients with SCH were more likely to have poor overall sleep quality (15.1 vs.25.8 %, P = 0.018) and l less likely to stay up late on weekdays (54.7 vs. 23.9 % P < 0.001). In SCH group, exercise was the influencing factor of TSH (β= -0.224, P = 0.004), thyroid secretory capacity (β = 0.244, P = 0.006) and thyrotropin resistance (β = 0.206, P = 0.009). Iodine excess was the influencing factor of thyroid secretory capacity (β = 0.209, P = 0.001) and pituitary thyroid stimulating function (β = 0.167, P = 0.034). Smoking was the influencing factor of pituitary thyroid stimulating function (β = 0.161, P = 0.040). Staying up late on weekends was the influencing factor of thyroid secretory capacity (β = 0.151, P = 0.047). After adjusting for possible confounders, logistic regression showed that those with poor overall sleep quality assessed by PSQI and iodine excess had an increased risk of SCH (OR 2.159, 95 %CI 1.186–3.928, P = 0.012 and OR 2.119, 95 %CI 1.008–4.456, P = 0.048, respectively).ConclusionsLifestyle including sleep, smoking, diet and exercise was closely related to thyroid function especially thyroid homeostasis in SCH.

【 授权许可】

CC BY