Outcome of in vitro fertilization in women with subclinical hypothyroidism

Reproductive Biology and Endocrinology

Research

Ben Niu¹  RuiJin Guo¹  YunYing Cai²  Heng Su²  Jie Guan³  LanPing Zhong³  YanPing Ma³ 

[1] Department of Endocrinology, The Affiliated Hospital of Kunming University of Science and Technology, The First People’s Hospital of Yunnan, 650032, Kunming, Yunnan Province, People’s Republic of China;Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, 650500, Kunming, Yunnan Province, People’s Republic of China;Department of Endocrinology, The Affiliated Hospital of Kunming University of Science and Technology, The First People’s Hospital of Yunnan, 650032, Kunming, Yunnan Province, People’s Republic of China;Reproductive Medicine Center, The Affiliated Hospital of Kunming University of Science and Technology, The First People’s Hospital of Yunnan, 650032, Kunming, Yunnan, People’s Republic of China;

关键词: Thyroid function;    in vitro fertilization;    Controlled ovarian stimulation;    Subclinical hypothyroidism;    Infertility;   

DOI  :  10.1186/s12958-017-0257-2

 received in 2017-03-29, accepted in 2017-05-14,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundPrevious studies examining associations between subclinical hypothyroidism (SCH) with in vitro fertilization (IVF) outcome indicate some benefits of levothyroxine (LT4) treatment. But IVF outcomes in treated SCH women whose serum Thyroid Stimulating Hormone (TSH) concentration did and did not exceed 2.5 mIU/L before the IVF cycle has not been studied thoroughly.MethodsIn this study, we performed a prospective cohort study with 270 treated subclinical hypothyroidism patients undergoing their first IVF retrieval cycle at a single cite.ResultsSCH in women receiving LT4 replacement with a basal TSH level between 0.2-2.5mIU/L displayed a similar rate of clinical pregnancy (47.4% vs 38.7%, P = .436), miscarriage (7.4% vs 16.7%, P = .379) and live birth (43.9% vs 32.3%, P = .288) compared to women with a basal TSH level between 2.5-4.2 mIU/L.ConclusionStrictly controlled TSH (less than 2.5 mIU/L) before IVF may have no effect on the pregnancy rate in LT4 treated SCH women.

【 授权许可】

CC BY   
© The Author(s). 2017