Soluble ST2 and risk of cognitive impairment after acute ischemic stroke: a prospective observational study

BMC Geriatrics

Tan Xu¹  Qi Zhang¹  Rui Zhang¹  Yinwei Zhu¹  Yaling Lu¹  Chongquan Fang¹  Aili Wang¹  Yonghong Zhang¹  Chongke Zhong¹  Xiaoqing Bu²  Zhong Ju³  Jintao Zhang⁴ 

[1] Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, 199 Renai Road, Industrial Park District, 215123, Suzhou, Jiangsu Province, China;Department of Epidemiology, School of Public Health, Chongqing Medical University, Chongqing, China;Department of Neurology, Kerqin District First People’s Hospital of Tongliao City, Tongliao, Inner Mongolia, China;Department of Neurology, The 88th Hospital of PLA, Taian, Shandong, China;

关键词: Ischemic stroke;    sST2;    Cognitive impairment;    Montreal cognitive assessment;    Mini-mental state examination;   

DOI  :  10.1186/s12877-021-02288-6

来源: Springer

【 摘 要 】

BackgroundSoluble suppression of tumorigenesis-2 (sST2) was reported to be associated with cognitive performance and risk of incident stroke. However, the impact of sST2 on cognitive function after ischemic stroke is unclear. We aimed to assess the association of sST2 and cognitive impairment at 3 months in acute ischemic stroke patients.MethodsBaseline plasma sST2 levels were measured in 619 ischemic stroke patients (mean age: 60.0 ± 10.5 years) from 7 participating hospitals of the China Antihypertensive Trial in Acute Ischemic Stroke. Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE) were used to assess cognitive status. Cognitive impairment was defined as a MoCA score < 23 or MMSE score < 27. The association between sST2 and cognitive impairment was evaluated by logistic regression analysis.Results325 (52.5%) or 323 (52.2%) participants developed cognitive impairment according to MoCA or MMSE. After adjustment for age, sex, education, and other covariates, the odds ratio for the highest vs lowest quartile of sST2 was 2.38 (95% CI, 1.42–4.00) and 1.82 (95% CI 1.09–3.03) risk of cognitive impairment defined by MoCA and MMSE score, respectively. Incorporation sST2 into a model containing conventional risk factors significantly improved reclassification.ConclusionsElevated plasma sST2 levels were significantly associated with post-stroke cognitive impairment.

【 授权许可】

CC BY