Cognitive dysfunctions and psychological symptoms in migraine without aura: a cross-sectional study

The Journal of Headache and Pain

Research Article

Fabrizia Falco¹  Federica Garramone¹  Gabriella Santangelo²  Mattia Siciliano²  Luigi Trojano³  Laura Marcuccio⁴  Alessandro Tessitore⁴  Antonio Russo⁴  Francesca Conte⁴  Gioacchino Tedeschi⁴ 

[1] Department of Psychology, Second University of Naples, 81100, Caserta, Italy;Department of Psychology, Second University of Naples, 81100, Caserta, Italy;Institute for Diagnosis and Care “Hermitage Capodimonte”, 80100, Naples, Italy;Department of Psychology, Second University of Naples, 81100, Caserta, Italy;Salvatore Maugeri Foundation, Scientific Institute of Telese, 82037, Telese Terme, BN, Italy;Headache Center, Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, 80138, Naples, Italy;Institute for Diagnosis and Care “Hermitage Capodimonte”, 80100, Naples, Italy;

关键词: Migraine;    Cognitive deficits;    Depression;    Apathy;    MoCA;    Montreal cognitive assessment;   

DOI  :  10.1186/s10194-016-0667-0

 received in 2016-07-05, accepted in 2016-08-17,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundThe occurrence of cognitive dysfunctions and psychological symptoms, as well as their mutual relationships, in migraine patients are still debated. The aim of the study was to characterize the cognitive profile and psychological symptoms (i.e. depression, anxiety and apathy) in drug-naïve migraine without aura (MwoA) patients.MethodsSeventy-two consecutive MwoA patients, referred to the Italian University Headache Clinic and 72 healthy subjects (HCs) were enrolled. Patients, during an attack-free period, and HCs completed Montreal Cognitive Assessment (MoCA), Beck Depression Inventory-II (BDI-II), Self-version of Apathy Evaluation Scale (AES-S) and State and Trait Anxiety Inventory (STAI-Y-1 and 2). Clinical parameters of disease severity (i.e. disease duration, migraine attacks per month, mean pain intensity during migraine attacks, migraine disability and impact on daily life) were recorded.ResultsAlthough performance of MwoA patients on MoCA was above Italian cut-off threshold (<15.5) suggesting presence of cognitive impairment, MwoA patients achieved significantly lower scores than HCs on total MoCA scale (22.3 ± 2.7 versus 25.4 ± 2.3) and on its attention (4.9 ± 1.1 versus 5.6 ± 0.7), memory (1.8 ± 1.4 versus 3.1 ± 1.3), visuospatial (3.2 ± 0.9 versus 3.6 ± 0.6) and executive subscales (2.6 ± 1.1 versus 3.1 ± 0.8). In addition, we observed significant correlations between MoCA executive domain subscore and the attack-related disability score (MIDAS).As for behavioral profile, the percentage of depressive symptoms (4.2 %), high state and trait anxiety (13.9 and 9.7 %, respectively), and apathy (11.1 %) in MwoA patients were similar to that of HCs. No significant associations of behavioural symptoms with cognitive performance and clinical parameters were found.ConclusionsDrug-naïve MwoA patients are characterized by subtle cognitive dysfunctions and low percentage of behavioural symptoms. The results support the importance of searching for subclinical cognitive disturbances in patients with MwoA, who deserve to be followed-up to verify whether they develop clinically relevant disorders over time.

【 授权许可】

CC BY   
© The Author(s). 2016