The risk of carotid plaque instability in patients with metabolic syndrome is higher in women with hypertriglyceridemia

Cardiovascular Diabetology

Manuela Montanaro¹  Erica Giacobbi¹  Francesca Servadei¹  Lucia Anemona¹  Rita Bonfiglio²  Manuel Scimeca³  Alessandro Mauriello⁴  Massimo Federici⁵  Annalisa Noce⁵  Iacopo Maria Legramante⁵  Marina Cardellini⁵  Patrizia Borboni⁵  Nicola Di Daniele⁵  Francesca Di Daniele⁶  Valentina Rovella⁷  Arnaldo Ippoliti⁸ 

[1] Anatomic Pathology, Department of Experimental Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133, Rome, RM, Italy;Anatomic Pathology, Department of Experimental Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133, Rome, RM, Italy;Fondazione Umberto Veronesi (FUV), Piazza Velasca 5, 20122, Milano, MI, Italy;Anatomic Pathology, Department of Experimental Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133, Rome, RM, Italy;San Raffaele University, Via di Val Cannuta 247, 00166, Rome, Italy;Saint Camillus International University of Health Sciences, Via di Sant’Alessandro, 8, 00131, Rome, Italy;Anatomic Pathology, Department of Experimental Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133, Rome, RM, Italy;Tor Vergata Oncoscience Research (TOR), University of Rome “Tor Vergata“, Rome, Italy;Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy;PhD School of Applied Medical, Surgical Sciences, University of Rome Tor Vergata, Rome, Italy;UOC of Internal Medicine, Center of Hypertension, University of Rome Tor Vergata, Rome, Italy;Vascular Surgery, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy;

关键词: Metabolic syndrome;    Carotid;    Histology;    Hypertriglyceridemia;    Post‐menopause;   

DOI  :  10.1186/s12933-021-01277-8

来源: Springer

【 摘 要 】

BackgroundMetabolic syndrome certainly favors growth of carotid plaque; however, it is uncertain if it determines plaque destabilization. Furthermore, it is likely that only some components of metabolic syndrome are associated with increased risk of plaque destabilization. Therefore, we evaluated the effect of different elements of metabolic syndrome, individually and in association, on carotid plaques destabilization.MethodsA total of 186 carotid endarterectomies from symptomatic and asymptomatic patients were histologically analysed and correlated with major cardiovascular risk factors.ResultsMetabolic syndrome, regardless of the cluster of its components, is not associated with a significant increase in risk of plaque destabilization, rather with the presence of stable plaques. The incidence of unstable plaques in patients with metabolic syndrome is quite low (43.9 %), when compared with that seen in the presence of some risk factors, but significantly increases in the subgroup of female patients with hypertriglyceridemia, showing an odds ratio of 3.01 (95% CI, 0.25–36.30).ConclusionsOur data may help to identify patients with real increased risk of acute cerebrovascular diseases thus supporting the hypothesis that the control of hypertriglyceridemia should be a key point on prevention of carotid atherosclerotic plaque destabilization, especially in post-menopausal female patients.

【 授权许可】

CC BY