Chemotherapy in idiopathic pulmonary fibrosis and small-cell lung cancer with poor lung function

BMC Pulmonary Medicine

Xiyue Zhang¹  Zhenzhong Su¹  Wei Li¹  Chunyan Li¹  Jie Zhang¹ 

[1] Department of Respiratory and Critical Care Medicine, The Second Hospital of Jilin University, Changchun, Jilin, China;

关键词: Small-cell lung cancer;    Idiopathic pulmonary fibrosis;    Chemotherapy;   

DOI  :  10.1186/s12890-021-01489-4

来源: Springer

【 摘 要 】

BackgroundIdiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease with unclear pathogenesis. IPF is considered as a risk factor for lung cancer. Compared to other lung cancers, small-cell lung cancer (SCLC) has a lower incidence, but has a more aggressive course. Patients with IPF and SCLC have a lower survival rate, more difficult treatment, and poorer prognosis.Case presentationCase 1 was of a 66-year-old man with IPF for 5 years, who was admitted to our hospital for dyspnea. Case 2 was of a 68-year-old woman, who presented with chest pains, cough, and dyspnea. Both patients had extremely poor lung function. High-resolution computed tomography and pathology revealed that both patients had IPF and SCLC. Chemotherapy comprising nedaplatin (80 mg/m2) and etoposide (100 mg for 5 days) was initiated for both patients. Antifibrotic agents were continued during the chemotherapeutic regimen. Both patients showed improvement in their condition after treatment.ConclusionThe favorable outcomes in these 2 cases suggests that chemotherapy is worth considering in the management of patients having SCLC and IPF with poor lung function.

【 授权许可】

CC BY