Comparison of clinical features on admission between coronavirus disease 2019 and influenza a among children: a retrospective study in China

BMC Infectious Diseases

Feng Liang¹  Kuanrong Li¹  Huimin Xia²  Huiying Liang²  Lei Liu³  Yi Xu⁴  Sitang Gong⁵  Liya He⁵  Xianfeng Wang⁶  Jun Chen⁶  Hui Li⁷  Jianbo Shao⁷ 

[1] Clinical Data Center, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, 510623, Guangzhou, Guangdong, China;Clinical Data Center, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, 510623, Guangzhou, Guangdong, China;Guangdong Provincial Children’s Medical Research Center, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China;Department of Infectious Disease, The Third People’s Hospital of Shenzhen, 518112, Shenzhen, Guangdong, China;Department of Pediatric, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China;Department of Pediatric, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China;Guangdong Provincial Children’s Medical Research Center, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China;Department of Pediatric, The Third People’s Hospital of Shenzhen, Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong, China;Department of Pediatric, Wuhan Children’s Hospital, 430000, Wuhan, Hubei, China;

关键词: Coronavirus disease 2019;    Influenza a;    Pediatrics;    Retrospective study;   

DOI  :  10.1186/s12879-021-06037-3

来源: Springer

【 摘 要 】

BackgroundCoronavirus disease 2019 (COVID-19) share similar symptoms with influenza A (IA), but it is more worthwhile to understand the disparities of the two infections regarding their clinical characteristics on admission.MethodsA total of 71 age-matched pediatric IA and COVID-19 patient pairs were formed and their clinical data on admission were compared.ResultsFever, cough, nasal congestion and nausea/vomiting were the most common symptoms on admission for both infections but occurred less often in COVID-19. The IA patients were more likely to have lower-than-normal levels of lymphocyte count and percentage and to have higher-than-normal levels of activated partial thromboplastin time, prothrombin time, serum C-reactive protein, and serum procalcitonin, while the COVID-19 patients had higher odds of having lower-than-normal levels of neutrophil count and percentage.ConclusionsThis study suggests that influenza A is more symptomatic than COVID-19 for children and might be an overall more severe infection at the time of admission.

【 授权许可】

CC BY