MSC-derived exosomes carrying a cocktail of exogenous interfering RNAs an unprecedented therapy in era of COVID-19 outbreak

Journal of Translational Medicine

Monire Jamalkhah¹  Yasaman Asaadi¹  Ehsan Arefian²  Jafar Kiani³  Masoud Soleimani⁴  Mohammadreza Azangou-Khyavy⁵  Javad Khanali⁵ 

[1] Department of Biotechnology, College of Science, University of Tehran, Tehran, Iran;Department of Microbiology, School of Biology, College of Science, University of Tehran, Tehran, Iran;Department of Molecular Medicine, School of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran;Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;

关键词: Mesenchymal stem cells;    COVID-19;    SARS-CoV-2;    Exosomes;    RNA interference;    COVID-19 therapy;   

DOI  :  10.1186/s12967-021-02840-3

来源: Springer

【 摘 要 】

BackgroundThe onset of the SARS-CoV-2 pandemic has resulted in ever-increasing casualties worldwide, and after 15 months, standard therapeutic regimens are yet to be discovered.Main bodyDue to the regenerative and immunomodulatory function of MSCs, they can serve as a suitable therapeutic option in alleviating major COVID-19 complications like acute respiratory distress syndrome. However, the superior properties of their cognate exosomes as a cell-free product make them preferable in the clinic. Herein, we discuss the current clinical status of these novel therapeutic strategies in COVID-19 treatment. We then delve into the potential of interfering RNAs incorporation as COVID-19 gene therapy and introduce targets involved in SARS-CoV-2 pathogenesis. Further, we present miRNAs and siRNAs candidates with promising results in targeting the mentioned targets.ConclusionFinally, we present a therapeutic platform of mesenchymal stem cell-derived exosomes equipped with exogenous iRNAs, that can be employed as a novel therapeutic modality in COVID-19 management aiming to prevent further viral spread within the lung, hinder the virus life cycle and pathogenesis such as immune suppression, and ultimately, enhance the antiviral immune response.

【 授权许可】

CC BY