Occupational exposure to glyphosate and risk of lymphoma:results of an Italian multicenter case-control study

Environmental Health

Federico Meloni¹  Giannina Satta¹  Alessandra Argiolas¹  Sara De Matteis¹  Pierluigi Cocco¹  Marcello Campagna¹  Ilaria Pilia¹  Mariagrazia Zucca¹  Giacomo Muzi²  Andrea Montagna²  Angela Gambelunghe²  Aldo Scarpa³  Roberta Zanotti³  Marina Padoan⁴  Corrado Magnani⁴  Sara Piro⁵  Lucia Miligi⁵  Luigi Vimercati⁶  Giovanni Maria Ferri⁶ 

[1] Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy;Department of Medicine and Surgery, Occupational Medicine, Respiratory Diseases and Toxicology Section, University of Perugia, Perugia, Italy;Department of Medicine, Haematology Unit, and Department of Diagnostics and Public Health-Section of Pathology, Verona University Hospital, Verona, Italy;Department of Translational Medicine, Unit of Medical Statistics and Cancer Epidemiology, University of Eastern Piedmont, Novara, Italy;Environmental and Occupational Epidemiology Branch - Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy;Interdisciplinary Department of Medicine (DIM), Unit of Occupational Medicine, University of Bari, Bari, Italy;

关键词: Glyphosate;    Follicular lymphoma;    Occupational exposure;    Pesticides;    Occupational cancer;   

DOI  :  10.1186/s12940-021-00729-8

来源: Springer

【 摘 要 】

BackgroundThe International Agency for Research on Cancer (IARC) recently classified glyphosate, the most used herbicide worldwide, as a probable human carcinogen. We inquired into the association between occupational exposure to glyphosate and risk of lymphoma subtypes in a multicenter case-control study conducted in Italy.MethodsThe Italian Gene-Environment Interactions in Lymphoma Etiology (ItGxE) study took place in 2011–17 in six Italian centres. Overall, 867 incident lymphoma cases and 774 controls participated in the study. Based on detailed questionnaire information, occupational experts classified duration, confidence, frequency, and intensity of exposure to glyphosate for each study subject. Using unconditional regression analysis, we modelled risk of major lymphoma subtypes associated with exposure to glyphosate adjusted by age, gender, education, and study centre.ResultsVery few study subjects (2.2%) were classified as ever exposed to glyphosate. Risk of follicular lymphoma (FL) was elevated 7-fold in subjects classified as ever exposed to glyphosate with medium-high confidence, 4.5-fold in association with medium-high cumulative exposure level, 12-fold with medium-high exposure intensity, and 6-fold with exposure for 10 days or more per year. Significant upward trends were detected with all the exposure metrics, but duration. The overall p-value for an upward trend with four independent metrics was 1.88 × 10− 4. There was no association with risk of lymphoma (any subtype), Non Hodgkin Lymphoma, B-cell lymphoma, or the major lymphoma subtypes other than FL.ConclusionsOur findings provide limited support to the IARC decision to classify glyphosate as Group 2A human carcinogen.

【 授权许可】

CC BY