Sex and onset-age-related features of excessive daytime sleepiness and night-time sleep in patients with Parkinson’s disease

BMC Neurology

Kai Li¹  Man-Hua Liu¹  Ming Liu¹  Jing Chen¹  Yun Shen¹  Sheng Zhuang¹  Hong Jin¹  Han-Ying Gu¹  Cheng-Jie Mao¹  Yi-Ming Wang¹  Jiao Li¹  Ya-Jun Luo¹  Chun-Feng Liu² 

[1] Department of Neurology and Suzhou Clinical Research Center of Neurological Diseases, the Second Affiliated Hospital of Soochow University, 215004, Suzhou, Jiangsu Province, China;Department of Neurology and Suzhou Clinical Research Center of Neurological Diseases, the Second Affiliated Hospital of Soochow University, 215004, Suzhou, Jiangsu Province, China;Department of Neurology, Suqian First Hospital, Suqian, China;

关键词: Parkinson’s disease;    Sex difference;    Age at onset;    Excessive daytime sleepiness;    Nocturnal sleep quality;   

DOI  :  10.1186/s12883-021-02192-x

来源: Springer

【 摘 要 】

BackgroundThe clinical characteristics of Parkinson’s disease (PD) differ between men and women, and late- and early-onset patients, including motor symptoms and some nonmotor symptoms, such as cognition, anxiety, and depression.ObjectiveTo explore the features of excessive daytime sleepiness (EDS) and night-time sleep quality in PD patients of different sexes and age at onset (AAO).MethodsDemographic data and clinical characteristics of 586 PD patients were collected. Epworth Sleepiness Scale (ESS) and Pittsburgh Sleep Quality Index (PSQI) were used to investigate the daytime drowsiness and nocturnal sleep. Multivariate logistic regression analysis was used to explore the risk factors of EDS and poor night-time sleep quality.ResultsSleep disorders were common in PD patients. EDS was more prominent in men than in women. There was no significant difference in ESS scores between late-onset PD (LOPD) and early-onset PD. LOPD patients had a higher probability of poor night-time sleep quality. Male sex, disease duration, and depression were risk factors for EDS. In all patients of both sexes and all AAO, depression was a risk factor for poor night-time sleep.ConclusionMore attention should be paid to sleep disorders of PD patients, especially male LOPD patients. Depression is a common risk factor for EDS and poor sleep quality in PD patients.

【 授权许可】

CC BY