Is Apolipoprotein E ε2 Associated with Delayed Onset of Non-Lesional Temporal Lobe Epilepsy?

Acta Clinica Croatica

Silvio Bašić¹  Darija Mahović Lakušić²  Davor Sporiš³  Tomislav Babić⁴  Jadranka Sertić⁵ 

[1] Dubrava University Hospital, Department of Neurology;Department of Neurology, Zagreb, Croatia;Osijek School of Medicine, Josip Juraj Strossmayer University, Osijek;Worldwide Clinical Trials, London, UK;Zagreb University Hospital Center, Clinical Institute of Laboratory Diagnosis;

关键词: Apolipoprotein E2;    Polymorphism, genetic;    Epilepsy, temporal lobe;    Age at onset;   

DOI  :  

来源: DOAJ

【 摘 要 】

The aim of the study was to evaluate the possible association between Apo E polymorphisms and age at seizure onset in patients with non-lesional temporal lobe epilepsy. Eighty patients with non-lesional temporal lobe epilepsy with or without bilateral tonic-clonic propagation were analyzed. Age at seizure onset was defined as age at the first unequivocal seizure (excluding febrile convulsions). ApoE alleles were determined by a procedure where genome DNA was amplified by chain reaction along with polymerase, using the LightCycler kit (Roche) for ApoE mutations on codons 112 and 158. There was a statistically significant difference between the groups of patients with ApoE ε2/3 and ε3/4 genotypes (p=0.03), but not between patients with ApoE ε2/3 and ε3/3, and those with ApoE ε3/4 and ε3/3. In conclusion, the results of our study suggested positive association of a specific ApoE genotype and onset of non-lesional temporal lobe epilepsy.

【 授权许可】

Unknown