Assessment of cognitive functions in patients with multiple sclerosis applying the normative values of the Rao’s brief repeatable battery in the Portuguese population

BMC Neurology

Aristides Ferreira¹  Ana Margarida Passos¹  Mariana Rigueiro-Neves¹  Maria José Sá²  Claudia Sousa³ 

[1] BRU-IUL, Instituto Universitário de Lisboa (ISCTE-IUL), Lisbon, Portugal;MS Clinic, Department of Neurology, Centro Hospitalar Universitário São João Porto, Alameda Prof. Hernâni Monteiro, Porto, Portugal;Faculty of Health Sciences, University Fernando Pessoa, Porto, Portugal;MS Clinic, Department of Neurology, Centro Hospitalar Universitário São João Porto, Alameda Prof. Hernâni Monteiro, Porto, Portugal;Neuropsychological Unit, Department of Psychology, Centro Hospitalar Universitário São João Porto, Alameda Prof. Hernâni Monteiro, 4200 – 319, Porto, Portugal;

关键词: Multiple sclerosis;    Cognition;    Neuropsychological test;    Brief repeatable battery of neuropsychological tests;    Normative data;    Cognitive assessment;   

DOI  :  10.1186/s12883-021-02193-w

来源: Springer

【 摘 要 】

BackgroundThe Brief Repeatable Battery of Neuropsychological Tests (BRBN-T) is one of the most sensitive and used measures for detecting cognitive impairment in Multiple Sclerosis (MS).ObjectiveThe aim of this study was to adapt and validate this battery to the Portuguese population of MS patients.MethodsThe Portuguese version of the BRBN-T was applied to a stratified control national sample of 326 individuals considering sex, age, educational level and geographic location and also a clinical sample of 115 MS patients from several national hospitals. Through the exploration of its psychometrics properties, the Portuguese BRBN-T norms were produced.ResultsThe normative data is presented as a regression-based formula to adjust test scores for gender, education and age, and the results reveal the BRBN-T has the ability to differentiate between MS patients and healthy participant’s cognitive performance.ConclusionThis study demonstrated in our clinical population a good ability to detect cognitive impairment. Its clearly contributed to reinforcing the neuropsychological assessment in Portugal in patients with MS, by providing a new set of instruments, which can be used in the clinical practice, and in future studies. Moreover, it will allow a rigorous and precise support in relation to neuropsychological assessment for future longitudinal studies and clinical trials.

【 授权许可】

CC BY