Plasma membrane integrity: implications for health and disease

BMC Biology

Dustin A. Ammendolia¹  John H. Brumell²  William M. Bement³ 

[1]Cell Biology Program, Hospital for Sick Children, 686 Bay Street PGCRL, M5G 0A4, Toronto, ON, Canada

[2]Department of Molecular Genetics, University of Toronto, M5S 1A1, Toronto, ON, Canada

[3]Cell Biology Program, Hospital for Sick Children, 686 Bay Street PGCRL, M5G 0A4, Toronto, ON, Canada

[4]Department of Molecular Genetics, University of Toronto, M5S 1A1, Toronto, ON, Canada

[5]Institute of Medical Science, University of Toronto, M5S 1A1, Toronto, ON, Canada

[6]SickKids IBD Centre, Hospital for Sick Children, M5G 0A4, Toronto, ON, Canada

[7]Center for Quantitative Cell Imaging and Department of Integrative Biology, University of Wisconsin-Madison, 53706, Madison, WI, USA

关键词: Plasma membrane;    Membrane damage;    Lipid peroxidation;    Pore formation;    Membrane repair;    Vesicle trafficking;    Cell biology;    Tissue injury;    Disease;   

DOI  :  10.1186/s12915-021-00972-y

来源: Springer

【 摘 要 】

Plasma membrane integrity is essential for cellular homeostasis. In vivo, cells experience plasma membrane damage from a multitude of stressors in the extra- and intra-cellular environment. To avoid lethal consequences, cells are equipped with repair pathways to restore membrane integrity. Here, we assess plasma membrane damage and repair from a whole-body perspective. We highlight the role of tissue-specific stressors in health and disease and examine membrane repair pathways across diverse cell types. Furthermore, we outline the impact of genetic and environmental factors on plasma membrane integrity and how these contribute to disease pathogenesis in different tissues.

【 授权许可】

CC BY