Enhancement of Membrane Damage by Saponins Isolated from Acacia auriculiformis

The Japanese Journal of Pharmacology

Santi Prasad Sinha Babu²  Arpita Saha²  Debapriya Sarkar¹  Nirmal Chandra Sukul²  Naba Kumar Ghosh²  Shelley Bhattacharya¹ 

[1]Environmental Toxicology Laboratory, Department of Zoology, Visva-Bharati University

[2]Parasitology Laboratory, Department of Zoology, Visva-Bharati University

关键词: Saponin;    Membrane damage;    Lipid peroxidation;   

DOI  :  10.1254/jjp.75.451

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(11)Cited-By(9)Acaciaside A and B, two acylated triterpenoid bisglycosides isolated from the funicles of Acacia auriculiformis, are known to have antihelmintic activity. Since the saponins contain a conjugated unsaturated system that is highly susceptible to peroxidation, we investigated the interaction of saponins and membrane using rat liver microsomes as our model. Microsomal membranes were incubated with saponins at 30°C for 2 hr. Following incubation, lipid peroxidation was measured in terms of malondialdehyde and conjugated diene. Our results showed that incubation of microsomal membranes with saponins increased both malondialdehyde and conjugated diene. The results suggest that in our model, saponins enhance the membrane lipid peroxidation.

【 授权许可】

Unknown