A study of the correlation between M2 macrophages and lymph node metastasis of colorectal carcinoma

World Journal of Surgical Oncology

Jikun Wang¹  Chunyu Yang²  Yue Wang²  Xueqian Ma³  Jinhao Liu³  Zuoxiu Shi³  Yanping Wang³  Yang Feng³  Shifeng Qiao³  Yanlei Chen³ 

[1] Department of Oncology, The First Affiliated Hospital of Jinzhou Medical University, 121000, Jinzhou, Liaoning, People’s Republic of China;Department of Pathology, The First Affiliated Hospital of Jinzhou Medical University, 121000, Jinzhou, Liaoning, People’s Republic of China;The Second Ward of Colorectal Surgery, The First Affiliated Hospital of Jinzhou Medical University, No. 2, The Fifth Section of Renmin Street, Guta, 121000, Jinzhou, Liaoning, People’s Republic of China;

关键词: M2 macrophages;    CD163;    Colorectal carcinoma;    Lymph node metastasis;    Carcinoembryonic antigen;   

DOI  :  10.1186/s12957-021-02195-5

来源: Springer

【 摘 要 】

BackgroundLymph node metastasis is a major prognostic sign of colorectal carcinoma and an important indicator for individualized treatment. M2 macrophages play a key role in carcinogenesis and tumor development by enhancing invasiveness and promoting lymph node metastasis. The purpose of this study was to investigate the effect of CD163-positive M2 macrophages on lymph node metastasis in colorectal carcinoma.MethodsPostoperative lymph node tissues were obtained from 120 patients with colorectal carcinoma who underwent radical surgery in the First Affiliated Hospital of Jinzhou Medical University between December 2019 and May 2020. We detected the expression of the CD163 protein in lymph nodes using immunohistochemistry. Furthermore, the relationships between M2 macrophages identified by expression of CD163 and lymph node metastasis were analyzed using the independent sample t-test and Chi-square test.ResultsM2 macrophages were increased in metastatic lymph nodes and non-metastatic lymph nodes adjacent to the cancer. The M2 macrophage count was higher in patients with macro-metastases than in patients with micro-metastases.ConclusionsThe presence of M2 macrophages represents an important indicator for lymph node metastasis in colorectal carcinoma and may be a potential marker for its prediction. Thus, M2 macrophage localization might offer a new target for the comprehensive treatment of colorectal carcinoma.

【 授权许可】

CC BY