Bilateral facial nerve palsy associated with amphiphysin antibody in metastatic breast cancer: a case report

Journal of Medical Case Reports

Michail Charakidis¹  Vineet Kwatra¹  Narayan V. Karanth¹ 

[1] Medical Oncology Department, Alan Walker Cancer Centre, Royal Darwin Hospital, Northern Territory, Australia;

关键词: Facial nerve palsy;    Bell’s palsy;    Amphiphysin antibody;    Breast cancer;    Nab-paclitaxel;    Paraneoplastic syndrome;   

DOI  :  10.1186/s13256-021-02727-3

来源: Springer

【 摘 要 】

BackgroundParaneoplastic neurological syndrome is an immune-mediated phenomenon where antibodies from tumor cells are produced against neuronal proteins. Amphiphysin antibody is an onconeural antibody linked to the diagnosis of breast cancer and small-cell lung cancer. It is uncommon and typically associated with stiff-person syndrome, of which 90% of patients are eventually diagnosed with breast cancer.Case presentationWe present a case of a 47-year-old Caucasian woman with metastatic hormone receptor-positive breast cancer who developed bilateral facial nerve palsy while on treatment with nab-paclitaxel. The patient was found to have anti-amphiphysin antibody in the serum and cerebrospinal fluid. She was treated with methylprednisolone and intravenous immunoglobulin, which resulted in partial improvement in her facial nerve palsy.ConclusionsThis case highlights a rare presentation of bilateral facial nerve palsy that likely related to paraneoplastic syndrome associated with the presence of anti-amphiphysin antibody.

【 授权许可】

CC BY