Ethylene glycol intoxication following brake fluid ingestion complicated with unilateral facial nerve palsy: a case report

Journal of Medical Case Reports

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[1] 0000 0004 0493 4054, grid.416931.8, Department of Medicine, Teaching Hospital Kandy, Kandy, Sri Lanka;0000 0004 0493 4054, grid.416931.8, Department of Nephrology and Renal Transplant, Teaching Hospital Kandy, Kandy, Sri Lanka;

关键词: Ethylene glycol;    Brake fluid;    Intoxication;    Facial nerve palsy;   

DOI  :  10.1186/s13256-019-2139-z

来源: publisher

【 摘 要 】

BackgroundBrake oil is an automobile transmission fluid composed of a mixture of toxic alcohols such as ethylene glycols and glycol ethers. Both accidental and intentional ingestion cases have been reported and they can present with multisystem involvement. Life-threatening complications evolve from deleterious effects on cardiopulmonary and renal systems. Effects on neurological and gastrointestinal systems give rise to a multitude of complications although non-fatal in nature. The biochemical panel consists of a high concentration of ethylene glycol with severe metabolic acidosis, high anion gap, high osmolar gap, oxaluria, and hypocalcemia. The mainstay of treatment is enhanced elimination of ethylene glycol and its metabolites by hemodialysis, together with general supportive care, gastric decontamination, and vitamins such as thiamine and pyridoxine to minimize the adverse effects of intoxication.Case presentationA 26-year-old Sinhalese woman presented with reduced urine output, shortness of breath, reduced level of consciousness, abdominal pain, and vomiting with mild degree fever of 2 days’ duration. She had bilateral lower limb edema, crepitations over bilateral lower lung fields, and right-sided lower motor type facial nerve palsy. Investigations showed severe metabolic acidosis with high anion gap and high osmolar gap. With regular hemodialysis she made a complete recovery after 3 months.ConclusionEven without a clear history of poisoning, the presence of a high anion, high osmolar gap metabolic acidosis should prompt one to search for ethylene glycol ingestion. Uncommon manifestations like cranial neuropathies need to be examined and considered. Timely aggressive treatment leads to a better prognosis.

【 授权许可】

CC BY