Fluid proteomics of CSF and serum reveal important neuroinflammatory proteins in blood–brain barrier disruption and outcome prediction following severe traumatic brain injury: a prospective, observational study

Critical Care

Caroline Lindblad¹  Faiez Al Nimer²  Fredrik Piehl²  Eric Peter Thelin³  Bo-Michael Bellander⁴  Mikael Svensson⁴  Peter Nilsson⁵  Elisa Pin⁵  David Just⁵ 

[1] Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden;Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden;Center for Neurology, Academic Specialist Center, Stockholm Health Services, Stockholm, Sweden;Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden;Department of Neurology, Karolinska University Hospital, Stockholm, Sweden;Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden;Department of Neurosurgery, Karolinska University Hospital, Stockholm, Sweden;Division of Affinity Proteomics, Department of Protein Science, SciLifeLab, KTH-Royal Institute of Technology, Stockholm, Sweden;

关键词: Traumatic brain injury;    Protein biomarkers;    Proteomics;    Neuroinflammation;    Blood–brain barrier;    Apolipoprotein E4;    Glasgow Outcome Score;    Human;   

DOI  :  10.1186/s13054-021-03503-x

来源: Springer

【 授权许可】

CC BY