Genomic Sequence Comparisons, 1987-2003 Final Report

Church, George M.

Harvard Medical School, Boston, MA (United States)

关键词: Genomics;    Proteomics;    Recombination;    Rna Genomics;    59 Basic Biological Sciences;   

DOI  :  10.2172/827024
RP-ID  :  DOE/ER/60565-1
RP-ID  :  FG02-87ER60565
RP-ID  :  827024

美国|英语

来源: UNT Digital Library

【 摘 要 】

This project was to develop new DNA sequencing and RNA and protein quantitation methods and related genome annotation tools. The project began in 1987 with the development of multiplex sequencing (published in Science in 1988), and one of the first automated sequencing methods. This lead to the first commercial genome sequence in 1994 and to the establishment of the main commercial participants (GTC then Agencourt) in the public DOE/NIH genome project. In collaboration with GTC we contributed to one of the first complete DOE genome sequences, in 1997, that of Methanobacterium thermoautotropicum, a species of great relevance to energy-rich gas production.