The effects of moderate exercise and overtraining on learning and memory, hippocampal inflammatory cytokine levels, and brain oxidative stress markers in rats

The journal of physiological sciences

article

Zahra Jahangiri¹  Zahra Gholamnezhad¹  Mahmoud Hosseini¹  Farimah Beheshti⁴  Narges Kasraie⁶ 

[1] Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences;Neurogenic Inflammation Research Center, Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences;Division of Neurocognitive Sciences, Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences;Neuroscience Research Center, Torbat Heydariyeh University of Medical Sciences;Department of Physiology, School of Paramedical Sciences, Torbat Heydariyeh University of Medical Sciences;Rosenberg School of Optometry, University of the Incarnate Word

关键词: Moderate training;    Overtraining;    Learning;    Memory;    Inflammation;    Oxidative stress;   

DOI  :  10.1007/s12576-019-00719-z

来源: Springer

【 摘 要 】

To investigate the exercise intensity effects on rats’ memory and learning, animals were divided into control, moderate training (MT), and overtraining (OT) groups. At training last week, learning and memory was assessed using Morris water maze (MWM) and passive avoidance (PA) tests. Finally, the rat’s brains were removed for evaluating oxidative stress and inflammatory cytokines. Overtraining impaired animal’s performance in MWM and PA tests. In MT group, hippocampal levels of interleukin 1 beta (IL-1β) and malondialdehyde (MDA) increased, and thiol contents in hippocampal and cortical tissues decreased compared to control. In OT group, tumor necrosis factor α, IL-1β, and C-reactive protein hippocampal levels increased, MDA and nitric oxide metabolite in hippocampal and cortical tissues increased, thiol contents, catalase and superoxide dismutase activity in hippocampal and cortical tissues decreased compared to control and MT groups. Overtraining might lead to learning and memory impairment by increasing the inflammatory cytokine and oxidative stress markers.

【 授权许可】

Unknown