The Effect of Different Doses of Melatonin on Learning and Memory Deficit in Alzheimer Model of Rats

Caspian Journal of Neurological Sciences

article

Arman Keymoradzadeh¹  Alireza Komaki²  Arash ‌Bakhshi¹  Nafise Faraji²  Zoleikha Golipoor³  Parisa Shahshahani⁴ 

[1] Student Research Committee, School of Medicine, Guilan University of Medical Sciences;Neurophysiology Research Center, Hamadan University of Medical Sciences;Neuroscience Research Center, Guilan University of Medical Sciences;Department of Neurology, Poursina Hospital, Guilan University of Medical Sciences

关键词: Melatonin;    Alzheimer Disease;    Memory;    Learning;   

DOI  :  10.32598/CJNS.7.24.1

学科分类：社会科学、人文和艺术（综合）

来源: Presses Agronomiques De Gembloux

【 摘 要 】

Background: Alzheimer Disease (AD) is an age-related neurodegenerative disorder with a progressive impairment of cognitive function. The pineal gland hormone melatonin (MEL) has been known as a protection agent against AD. However, the effect of melatonin in various doses is inconsistent. Objectives: In this study, we aimed to investigate two doses of MEL on learning and memory in the amyloid-βeta (Aβ)-induced AD in the rats. Materials & Methods: Forty-eight male Wistar rats were used in the experiment and randomly divided control, sham, vehicle, AD, AD+MEL10 mg/kg, and AD+MEL 20 mg/kg groups. Intracerebroventricular injection of Aβ1–42 was used to develop the animal model of AD. Also, MEL-treated groups received an intraperitoneal injection of MEL for 4 next weeks. The Morris Water Maze (MWM) and Passive Avoidance Learning (PAL) tests were used to examine animals’ learning and memory. The brain of animals was removed for immunohistochemistry for anti- Amyloid Precursor Protein (APP). Results:0.05). Histopathological analysis revealed that the clearance of APP deposition in the AD+MEL20 group was considerable compared with the AD+MEL10 group (P=0.000). Conclusion: Our findings indicate that 10 and 20 mg/kg doses of melatonin have similar results on learning and memory in the AD model. But 20 mg/kg of melatonin has significantly more effect on the clearance of APP deposition.

【 授权许可】

CC BY-NC