Extracellular creatine kinase may modulate purinergic signalling

Purinergic signalling

article

L. M. Brewster¹ 

[1] CK Science Foundation

关键词: Creatine kinase;    ADP;    ATP;    Purinergic signalling;    ADP-dependent platelet aggregation;    Hypertension;   

DOI  :  10.1007/s11302-020-09707-0

学科分类：分子生物学，细胞生物学和基因

来源: Springer

【 摘 要 】

Extracellular purine nucleotides and nucleosides including ADP and ATP regulate a wide array of physiological processes including platelet aggregation, vasomotor responses and inflammation through specific purinergic receptors. In the recent years, a strong association has been reported between circulating cytoplasmic-type creatine kinase and adverse clinical outcomes such as major bleeding, hypertension and obesity. Therefore, it is proposed that extracellular CK may modulate purinergic signalling through its ADP binding and/or ATP-generating effect.

【 授权许可】

CC BY