Clinical characteristics of inpatients with coronavirus disease 2019 (COVID-19) in Sichuan province

BMC Infectious Diseases

Ou Jiang¹  Wen Wang²  Qiao He²  Mingqi Wang²  Xin Sun²  Mei Liu²  Wenhui Huan³  Fanxin Zeng⁴  Lei Chen⁵  Yongjun Chen⁶  Gang Mai⁷  Jianrong Yang⁸  Bo Long⁹  Wanzhi Fu^1,10  Wenquan Li^1,11  Zhiling Long^1,12  Juan Tang^1,13  Xiaoju Deng^1,14  Rongmei Li^1,15  Yihua Du^1,16  Taibing Deng^1,17  Yan Chen^1,18  Weimin Li^1,19  Zeqiang Wen^2,20  Xin Jiang^2,21 

[1] Cancer Center of the Second People’s Hospital of Neijiang, 641100, Neijiang, China;Chinese Evidence-based Medicine Center and Cochrane China Center, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, China;Department of Cardiology, Wusheng County People’s Hospital, 638400, Guang’an, China;Department of Clinical Research Center, Dazhou Central Hospital, 635000, Dazhou, China;Department of Clinical Research Management, West China Hospital, Sichuan University, 610041, Chengdu, China;Department of Gastroenterology, Suining Central Hospital, 629000, Suining, China;Department of Hepatopancreatobiliary Surgery, People’s Hospital of Deyang, 618000, Deyang, China;Department of Infectious Disease, Ganzi Hospital of West China Hospital, Sichuan University, 626000, Ganzi, China;Department of Infectious Disease, Sichuan Mianyang 404 Hospital, 621000, Mianyang, China;Department of Infectious Disease, The People’s Hospital of Jianyang, 641400, Jianyang, China;Department of Infectious Disease, The Second People’s Hospital of Yibin, West China Yibin Hospital, Sichuan University, 644000, Yibin, China;Department of Infectious Disease, Ya’An People’s Hospital, 625000, Ya’An, China;Department of Infectious Disease, Zigong First People’s Hospital, 643000, Zigong, China;Department of Oncology, The People’s Hospital of Yuechi, 638300, Yuechi, China;Department of Operation Management, West China Hospital, Sichuan University, 610041, Chengdu, China;Office of the Director, Jintang County First People’s Hospital, 610400, Chengdu, China;Department of Pediatric Surgery, The Affiliated Hospital of Southwest Medical University, 646000, Luzhou, China;Department of Respiratory Disease, Guang’An Hospital, 638001, Guangan, China;Department of Respiratory and Critical Care Medicine, Nanchong Central Hospital, 637000, Nanchong, China;Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, 610041, Chengdu, China;Department of Thoracic Surgery, The First People’s Hospital of Ziyang, 641300, Ziyang, China;Mianzhu People’s Hospital, 618200, Mianzhu, China;

关键词: Novel coronavirus;    COVID-19;    Clinical characteristics;   

DOI  :  10.1186/s12879-021-05825-1

来源: Springer

【 摘 要 】

BackgroundThe outbreak of COVID-19 has resulted in serious concerns in China and abroad. To investigate clinical features of confirmed and suspected patients with COVID-19 in west China, and to examine differences between severe versus non-severe patients.MethodsPatients admitted for COVID-19 between January 21 and February 11 from fifteen hospitals in Sichuan Province, China were included. Experienced clinicians trained with methods abstracted data from medical records using pre-defined, pilot-tested forms. Clinical characteristics between severe and non-severe patients were compared.ResultsOf the 169 patients included, 147 were laboratory-confirmed, 22 were suspected. For confirmed cases, the most common symptoms from onset to admission were cough (70·7%), fever (70·5%) and sputum (33·3%), and the most common chest CT patterns were patchy or stripes shadowing (78·0%); throughout the course of disease, 19·0% had no fever, and 12·4% had no radiologic abnormality; twelve (8·2%) received mechanical ventilation, four (2·7%) were transferred to ICU, and no death occurred. Compared to non-severe cases, severe ones were more likely to have underlying comorbidities (62·5% vs 26·2%, P = 0·001), to present with cough (92·0% vs 66·4%, P = 0·02), sputum (60·0% vs 27·9%, P = 0·004) and shortness of breath (40·0% vs 8·2%, P <  0·0001), and to have more frequent lymphopenia (79·2% vs 43·7%, P = 0·003) and eosinopenia (84·2% vs 57·0%, P = 0·046).ConclusionsThe symptoms of patients in west China were relatively mild, and an appreciable proportion of infected cases had no fever, warranting special attention.

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