Abdominal pain in patients with inflammatory bowel disease: association with single-nucleotide polymorphisms prevalent in irritable bowel syndrome and clinical management

BMC Gastroenterology

Stefan Begré¹  Brian M. Lang²  Niko Beerenwinkel²  Philipp Schreiner³  Henriette Heinrich³  Thomas Greuter³  Gerhard Rogler³  Martina Ledergerber³  Stephan R. Vavricka³  Luc Biedermann³  René Roth³  Jonas Zeitz⁴  Benjamin Misselwitz⁵  Alexander Siebenhüner⁶  Niklas Krupka⁷  Andreas Rickenbacher⁸  Matthias Turina⁸ 

[1] Department of Biomedical Research, Neurology, Inselspital and University Clinic of Bern, Bern, Switzerland;Department of Biosystems Science and Engineering, ETH Basel, Basel, Switzerland;SIB Swiss Institute of Bioinformatics, Basel, Switzerland;Department of Gastroenterology, University Hospital Zurich (USZ), Zurich University, Zurich, Switzerland;Department of Gastroenterology, University Hospital Zurich (USZ), Zurich University, Zurich, Switzerland;Center of Gastroenterology, Clinic Hirslanden, Zurich, Switzerland;Department of Gastroenterology, University Hospital Zurich (USZ), Zurich University, Zurich, Switzerland;Department of Visceral Surgery and Medicine, Inselspital Bern, University of Bern, Bern, Switzerland;Department of Oncology, Center of Hematology and Oncology University Hospital Zurich (USZ), Zurich University, Zurich, Switzerland;Department of Visceral Surgery and Medicine, Inselspital Bern, University of Bern, Bern, Switzerland;Department of Visceral Surgery, University Hospital Zurich (USZ), Zurich, Switzerland;

关键词: Single-nucleotide polymorphisms;    Abdominal pain;    Inflammatory bowel disease;    Ulcerative colitis;    Crohn’s disease;    Irritable bowel syndrome;   

DOI  :  10.1186/s12876-021-01622-x

来源: Springer

【 摘 要 】

BackgroundAbdominal pain is a frequent symptom in patients with inflammatory bowel disease (IBD) including Crohn’s disease (CD) and ulcerative colitis (UC). Pain can result from ongoing inflammation or functional disorders imitating irritable bowel syndrome (IBS). Several single-nucleotide polymorphisms (SNPs) have been associated with IBS. However, the impact of IBS genetics on the clinical course of IBD, especially pain levels of patients remains unclear.MethodsData of 857 UC and 1206 CD patients from the Swiss IBD Cohort Study were analysed. We tested the association of the maximum of the abdominal pain item of disease activity indices in UC and CD over the study period with 16 IBS-associated SNPs, using multivariate ANOVA models.ResultsIn UC patients, the SNPs rs1042713 (located on the ADRB2 gene) and rs4663866 (close to the HES6 gene) were associated with higher abdominal pain levels (P = 0.044; P = 0.037, respectively). Abdominal pain was not associated with any markers of patient management in a model adjusted for confounders. In CD patients, higher levels of abdominal pain correlated with the number of physician contacts (P < 10–15), examinations (P < 10–12), medical therapies (P = 0.023) and weeks of hospitalisation (P = 0.0013) in a multivariate model.ConclusionsWe detected an association between maximal abdominal pain in UC patients and two IBS-associated SNPs. Abdominal pain levels had a pronounced impact on diagnostic and therapeutic procedures in CD but not in UC patients.

【 授权许可】

CC BY