Metabolism of human pluripotent stem cells and differentiated cells for regenerative therapy: a focus on cardiomyocytes

Inflammation and Regeneration

Shugo Tohyama¹  Keiichi Fukuda¹  Yoshikazu Kishino¹  Jun Fujita¹  Sho Tanosaki² 

[1] Department of Cardiology, Keio University School of Medicine, Shinjuku, 160-8582, Tokyo, Japan;Department of Cardiology, Keio University School of Medicine, Shinjuku, 160-8582, Tokyo, Japan;Department of Emergency and Critical Care Medicine, Keio University School of Medicine, Shinjuku, 160-8582, Tokyo, Japan;

关键词: Metabolism;    Pluripotent stem cells;    Cardiomyocytes;    Regenerative therapy;   

DOI  :  10.1186/s41232-021-00156-9

来源: Springer

【 摘 要 】

Pluripotent stem cells (PSCs) exhibit promising application in regenerative therapy, drug discovery, and disease modeling. While several protocols for differentiating somatic cells from PSCs exist, their use is limited by contamination of residual undifferentiated PSCs and immaturity of differentiated somatic cells.The metabolism of PSCs differs greatly from that of somatic cells, and a distinct feature is required to sustain the distinct properties of PSCs. To date, several studies have reported on the importance of metabolism in PSCs and their derivative cells. Here, we detail advancements in the field, with a focus on cardiac regenerative therapy.

【 授权许可】

CC BY