Exercise Promotes Tissue Regeneration: Mechanisms Involved and Therapeutic Scope

Sports Medicine - Open

Review Article

Gururaja Vulugundam¹  Guoping Li²  Priyanka Gokulnath²  Chang Liu³  Xinying Wu³  Junjie Xiao³ 

[1] Biologics Development, Sanofi, Framingham, MA, USA;Cardiovascular Division of the Massachusetts General Hospital and Harvard Medical School, 02114, Boston, MA, USA;Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People’s Hospital of Nantong), School of Medicine, Shanghai University, 226011, Nantong, China;Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, School of Life Science, Shanghai University, 200444, Shanghai, China;

关键词: Exercise;    Tissue regeneration;    Muscle stem cells;    Neural stem cells;    Cardiomyocytes;    Molecular mechanism;    Regenerative therapy;   

DOI  :  10.1186/s40798-023-00573-9

 received in 2022-09-01, accepted in 2023-04-23,  发布年份 2023

来源: Springer

【 摘 要 】

Exercise has well-recognized beneficial effects on the whole body. Previous studies suggest that exercise could promote tissue regeneration and repair in various organs. In this review, we have summarized the major effects of exercise on tissue regeneration primarily mediated by stem cells and progenitor cells in skeletal muscle, nervous system, and vascular system. The protective function of exercise-induced stem cell activation under pathological conditions and aging in different organs have also been discussed in detail. Moreover, we have described the primary molecular mechanisms involved in exercise-induced tissue regeneration, including the roles of growth factors, signaling pathways, oxidative stress, metabolic factors, and non-coding RNAs. We have also summarized therapeutic approaches that target crucial signaling pathways and molecules responsible for exercise-induced tissue regeneration, such as IGF1, PI3K, and microRNAs. Collectively, the comprehensive understanding of exercise-induced tissue regeneration will facilitate the discovery of novel drug targets and therapeutic strategies.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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