Epigenetic regulation of satellite cell fate during skeletal muscle regeneration

Skeletal Muscle

卷:11

Bénédicte Chazaud¹  Edward Gardner²  Jimmy Massenet²  F. Jeffrey Dilworth² 

[1] Institut NeuroMyoGène, Université Claude Bernard Lyon 1, CNRS 5310, INSERM U1217, 8 Rockefeller Ave;

[2] Sprott Center for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute;

关键词: Muscle stem cells;    Regeneration;    Epigenetics;    Cell fate;    Duchenne muscular dystrophy;   

DOI  :  10.1186/s13395-020-00259-w

来源: DOAJ

【 摘 要 】

Abstract In response to muscle injury, muscle stem cells integrate environmental cues in the damaged tissue to mediate regeneration. These environmental cues are tightly regulated to ensure expansion of muscle stem cell population to repair the damaged myofibers while allowing repopulation of the stem cell niche. These changes in muscle stem cell fate result from changes in gene expression that occur in response to cell signaling from the muscle environment. Integration of signals from the muscle environment leads to changes in gene expression through epigenetic mechanisms. Such mechanisms, including post-translational modification of chromatin and nucleosome repositioning, act to make specific gene loci more, or less, accessible to the transcriptional machinery. In youth, the muscle environment is ideally structured to allow for coordinated signaling that mediates efficient regeneration. Both age and disease alter the muscle environment such that the signaling pathways that shape the healthy muscle stem cell epigenome are altered. Altered epigenome reduces the efficiency of cell fate transitions required for muscle repair and contributes to muscle pathology. However, the reversible nature of epigenetic changes holds out potential for restoring cell fate potential to improve muscle repair in myopathies. In this review, we will describe the current knowledge of the mechanisms allowing muscle stem cell fate transitions during regeneration and how it is altered in muscle disease. In addition, we provide some examples of how epigenetics could be harnessed therapeutically to improve regeneration in various muscle pathologies.

【 授权许可】

Unknown