Role of melatonin in the angiogenesis potential; highlights on the cardiovascular disease

Journal of Inflammation

Marefat Siahkouhian¹  Lotfali Bolboli¹  Afshin Rahbarghazi²  Rana Keyhanmanesh³  Hadi Rajabi⁴  Mahdi Mahdipour⁴  Mahdi Ahmadi⁵  Reza Rahbarghazi⁶ 

[1] Department of Physical Education and Sports Sciences, Faculty of Educational Science & Psychology, University of Mohaghegh Ardabili, Daneshgah Street, Ardabil, Iran;Department of Physical Education and Sports Sciences, Faculty of Educational Science & Psychology, University of Mohaghegh Ardabili, Daneshgah Street, Ardabil, Iran;Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;Department of Applied Cell Sciences, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran;

关键词: Melatonin;    Angiogenesis;    Cardiovascular disease;    Regeneration;   

DOI  :  10.1186/s12950-021-00269-5

来源: Springer

【 摘 要 】

Melatonin possesses multi-organ and pleiotropic effects with potency to control angiogenesis at both molecular and cellular levels. To date, many efforts have been made to control and regulate the dynamic of angiogenesis modulators in a different milieu. The term angiogenesis or neovascularization refers to the development of de novo vascular buds from the pre-existing blood vessels. This phenomenon is tightly dependent on the balance between the pro- and anti-angiogenesis factors which alters the functional behavior of vascular cells. The promotion of angiogenesis is thought to be an effective strategy to accelerate the healing process of ischemic changes such as infarcted myocardium. Of note, most of the previous studies have focused on the anti-angiogenesis capacity of melatonin in the tumor niche. To the best of our knowledge, few experiments highlighted the melatonin angiogenesis potential and specific regulatory mechanisms in the cardiovascular system. Here, we aimed to summarize some previous experiments related to the application of melatonin in cardiovascular diseases such as ischemic injury and hypertension by focusing on the regulatory mechanisms.

【 授权许可】

CC BY