Differences of blood cells, lymphocyte subsets and cytokines in COVID-19 patients with different clinical stages: a network meta-analysis

BMC Infectious Diseases

Xu Wang¹  Francis Manyori Bigambo²  Wu Yan²  Danrong Chen²  Hongcheng Wei²  Yankai Xia² 

[1] Department of Endocrinology, Children’s Hospital of Nanjing Medical University, 210008, Nanjing, China;State Key Laboratory of Reproductive Medicine, Center for Global Health, School of Public Health, Nanjing Medical University, No.101 Longmian Road, Nanjing, 211166, Nanjing, China;Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, 211166, Nanjing, Jiangsu, China;

关键词: COVID-19;    Clinical stages;    Blood cells;    Lymphocyte subsets;    Cytokines;    Network meta-analysis;   

DOI  :  10.1186/s12879-021-05847-9

来源: Springer

【 摘 要 】

BackgroundDue to the rapid spread of coronavirus disease 2019 (COVID-19) worldwide, it is necessary to ascertain essential immune inflammatory parameters that describe the severity of the disease and provide guidance for treatment. We performed network meta-analyses to determine differences in blood cells, lymphocyte subsets, and cytokines in COVID-19 patients with different clinical stages.MethodsDatabases were systematically searched to May 2, 2020, and updated on June 1, 2020. Network meta-analyses were conducted via Stata 15.0, and the mean difference (MD) and its 95% CI were used as the effect values of the pooled analysis.ResultsSeventy-one studies were included involving 8647 COVID-19 patients, White blood cell (WBC), neutrophil (NEUT), IL-6, and IL-10 counts increased significantly with worsening of the COVID-19, while lymphocyte (LYM) counts decreased. The levels of platelet (PLT), CD3+, CD4+, CD8+, and CD19+ cells in severe and critical patients were significantly lower than those in mild patients. IL-1β count was significantly elevated in critical patients.ConclusionsImmune suppression and inflammatory injury play crucial roles in the progression of COVID-19, and the identification of susceptible cells and cytokines provide guidance for the early and accurate treatment of COVID-19 patients.

【 授权许可】

CC BY