Autocrine activin A signalling in ovarian cancer cells regulates secretion of interleukin 6, autophagy, and cachexia

Journal of Cachexia, Sarcopenia and Muscle

Unni Nonstad¹  Anna van der Veen¹  Geir Bjørkøy²  Sonja Andersen²  Kristine Pettersen²  Bjørn Henning Grønberg³  Siver Moestue⁴  Jana Kim⁴  Estelle Lach‐Trifilieff⁵  Alain Schilb⁵  Christian Lambert⁵  Shinji Hatakeyama⁵  Carsten Jacobi⁵ 

[1] Centre of Molecular Inflammation Research, Department of Clinical and Molecular Medicine, NTNU‐Norwegian University of Science and Technology, Trondheim, Norway;Department of Biomedical Laboratory Science, Faculty of Natural Sciences, NTNU‐Norwegian University of Science and Technology, Trondheim, Norway;Centre of Molecular Inflammation Research, Department of Clinical and Molecular Medicine, NTNU‐Norwegian University of Science and Technology, Trondheim, Norway;Department of Cancer Research and Molecular Medicine, NTNU‐Norwegian University of Science and Technology, Trondheim, Norway;Clinic of Oncology, St. Olavs Hospital ‐ Trondheim University Hospital, Trondheim, Norway;Department of Circulation and Medical Imaging, Faculty of Medicine, NTNU‐Norwegian University of Science and Technology, Trondheim, Norway;Novartis Institutes for BioMedical Research Basel, Musculoskeletal Disease Area, Novartis Pharma AG, Basel, Switzerland;

关键词: Cachexia;    Autophagy;    IL‐6;    Activin;    Autocrine loop;   

DOI  :  10.1002/jcsm.12489

来源: Wiley

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